SOX2 and SOX2-MYC Reprogramming Process of Fibroblasts to the Neural Stem Cells Compromised by Senescence

Marta Winiecka-Klimek; Maciej Smolarz; Maciej P. Walczak; Jolanta Zieba; Krystyna Hulas-Bigoszewska; Blazej Kmieciak; Sylwester Piaskowski; Piotr Rieske; Dawid P. Grzela; Ewelina Stoczynska-Fidelus

doi:10.1371/journal.pone.0141688

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Open Access

Peer-reviewed

Research Article

SOX2 and SOX2-MYC Reprogramming Process of Fibroblasts to the Neural Stem Cells Compromised by Senescence

Marta Winiecka-Klimek ,

* E-mail: marta.winiecka-klimek@celther.com

Affiliations Department of Research and Development, Celther Polska, Lodz, Poland, Department of Tumor Biology, Medical University of Lodz, Lodz, Poland
⨯
Maciej Smolarz,

Affiliations Department of Research and Development, Celther Polska, Lodz, Poland, Department of Tumor Biology, Medical University of Lodz, Lodz, Poland
⨯
Maciej P. Walczak,

Affiliation Department of Research and Development, Celther Polska, Lodz, Poland
⨯
Jolanta Zieba,

Affiliations Department of Research and Development, Celther Polska, Lodz, Poland, Department of Tumor Biology, Medical University of Lodz, Lodz, Poland
⨯
Krystyna Hulas-Bigoszewska,

Affiliation Department of Research and Development, Celther Polska, Lodz, Poland
⨯
Blazej Kmieciak,

Affiliation Department of Medical Law, Chair of Human Sciences, Medical University of Lodz, Lodz, Poland
⨯
Sylwester Piaskowski,

Affiliations Department of Research and Development, Celther Polska, Lodz, Poland, Department of Tumor Biology, Medical University of Lodz, Lodz, Poland
⨯
Piotr Rieske,

Affiliations Department of Research and Development, Celther Polska, Lodz, Poland, Department of Tumor Biology, Medical University of Lodz, Lodz, Poland
⨯
Dawid P. Grzela ,

¶‡ These authors are joint senior authors on this work.

Affiliation Department of Research and Development, Celther Polska, Lodz, Poland
⨯
Ewelina Stoczynska-Fidelus

¶‡ These authors are joint senior authors on this work.

Affiliations Department of Research and Development, Celther Polska, Lodz, Poland, Department of Tumor Biology, Medical University of Lodz, Lodz, Poland
⨯

SOX2 and SOX2-MYC Reprogramming Process of Fibroblasts to the Neural Stem Cells Compromised by Senescence

Marta Winiecka-Klimek,
Maciej Smolarz,
Maciej P. Walczak,
Jolanta Zieba,
Krystyna Hulas-Bigoszewska,
Blazej Kmieciak,
Sylwester Piaskowski,
Piotr Rieske,
Dawid P. Grzela,
Ewelina Stoczynska-Fidelus

Published: November 4, 2015
https://doi.org/10.1371/journal.pone.0141688

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