IFN-λ Inhibits MiR-122 Transcription through a Stat3-HNF4α Inflammatory Feedback Loop in an IFN-α Resistant HCV Cell Culture System

Fatma Aboulnasr; Sidhartha Hazari; Satyam Nayak; Partha K. Chandra; Rajesh Panigrahi; Pauline Ferraris; Srinivas Chava; Ramazan Kurt; Kyongsub Song; Asha Dash; Luis A. Balart; Robert F. Garry; Tong Wu; Srikanta Dash

doi:10.1371/journal.pone.0141655

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Open Access

Peer-reviewed

Research Article

IFN-λ Inhibits MiR-122 Transcription through a Stat3-HNF4α Inflammatory Feedback Loop in an IFN-α Resistant HCV Cell Culture System

Fatma Aboulnasr,

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA-70112, United States of America
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Sidhartha Hazari,

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA-70112, United States of America
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Satyam Nayak,

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA-70112, United States of America
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Partha K. Chandra,

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA-70112, United States of America
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Rajesh Panigrahi,

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA-70112, United States of America
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Pauline Ferraris,

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA-70112, United States of America
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Srinivas Chava,

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA-70112, United States of America
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Ramazan Kurt,

Affiliation Department of Medicine, Division of Gastroenterology and Hepatology
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Kyongsub Song,

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA-70112, United States of America
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Asha Dash,

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA-70112, United States of America
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Luis A. Balart,

Affiliation Department of Medicine, Division of Gastroenterology and Hepatology
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Robert F. Garry,

Affiliation Microbiology and Immunology Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA-70112, United States of America
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Tong Wu,

Affiliation Pathology and Laboratory Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA-70112, United States of America
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Srikanta Dash

* E-mail: sdash@tulane.edu

Affiliations Pathology and Laboratory Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA-70112, United States of America, Department of Medicine, Division of Gastroenterology and Hepatology
⨯

IFN-λ Inhibits MiR-122 Transcription through a Stat3-HNF4α Inflammatory Feedback Loop in an IFN-α Resistant HCV Cell Culture System

Fatma Aboulnasr,
Sidhartha Hazari,
Satyam Nayak,
Partha K. Chandra,
Rajesh Panigrahi,
Pauline Ferraris,
Srinivas Chava,
Ramazan Kurt,
Kyongsub Song,
Asha Dash

Published: December 11, 2015
https://doi.org/10.1371/journal.pone.0141655

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