Hypergravity Provokes a Temporary Reduction in CD4+CD8+ Thymocyte Number and a Persistent Decrease in Medullary Thymic Epithelial Cell Frequency in Mice

• Ryosuke Tateishi ,

  Contributed equally to this work with: Ryosuke Tateishi, Nobuko Akiyama

  Affiliations Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan

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• Nobuko Akiyama ,

  Contributed equally to this work with: Ryosuke Tateishi, Nobuko Akiyama

  Affiliations Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan

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• Maki Miyauchi,

  Affiliations Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan

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• Riko Yoshinaga,

  Affiliations Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan

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• Hiroki Sasanuma,

  Affiliations Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan, Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The University of Tokyo, Tokyo, Japan

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• Takashi Kudo,

  Affiliations Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan, Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki, Japan, Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

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• Miki Shimbo,

  Affiliations Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan, Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki, Japan, Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

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• Masahiro Shinohara,

  Affiliations Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan, Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, JST, PRESTO, Kawaguchi, Saitama, Japan

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• Koji Obata,

  Affiliations Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan, Department of Physiology, Gifu University Graduate School of Medicine, Gifu, Japan

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• Jun-ichiro Inoue,

  Affiliation Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

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• Masaki Shirakawa,

  Affiliations Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan, JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Ibaraki, Japan

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• Dai Shiba,

  Affiliations Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan, JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Ibaraki, Japan

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• Hiroshi Asahara,

  Affiliations Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan, Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

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• Nobuaki Yoshida,

  Affiliations Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan, Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The University of Tokyo, Tokyo, Japan

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• Satoru Takahashi,

  Affiliations Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan, Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki, Japan, Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

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• Hironobu Morita ,

  * E-mail: taishin@ims.u-tokyo.ac.jp (TA); zunzunmorita@gmail.com (HM)

  Affiliations Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan, Department of Physiology, Gifu University Graduate School of Medicine, Gifu, Japan

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•  [ ... ],
• Taishin Akiyama

  * E-mail: taishin@ims.u-tokyo.ac.jp (TA); zunzunmorita@gmail.com (HM)

  Affiliations Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan

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