Repeated Aerosolized-Boosting with Gamma-Irradiated Mycobacterium bovis BCG Confers Improved Pulmonary Protection against the Hypervirulent Mycobacterium tuberculosis Strain HN878 in Mice

Seung Bin Cha; Woo Sik Kim; Jong-Seok Kim; Hongmin Kim; Kee Woong Kwon; Seung Jung Han; Seok-Yong Eum; Sang-Nae Cho; Sung Jae Shin

doi:10.1371/journal.pone.0141577

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Open Access

Peer-reviewed

Research Article

Repeated Aerosolized-Boosting with Gamma-Irradiated Mycobacterium bovis BCG Confers Improved Pulmonary Protection against the Hypervirulent Mycobacterium tuberculosis Strain HN878 in Mice

Seung Bin Cha ,

Contributed equally to this work with: Seung Bin Cha, Woo Sik Kim

Affiliation Department of Microbiology, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea
⨯
Woo Sik Kim ,

Contributed equally to this work with: Seung Bin Cha, Woo Sik Kim

Affiliation Department of Microbiology, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea
⨯
Jong-Seok Kim,

Affiliation Department of Microbiology, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea
⨯
Hongmin Kim,

Affiliations Department of Microbiology, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea
⨯
Kee Woong Kwon,

Affiliations Department of Microbiology, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea
⨯
Seung Jung Han,

Affiliation Department of Microbiology, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea
⨯
Seok-Yong Eum,

Affiliation Division of Immunopathology and Cellular Immunology, International Tuberculosis Research Center, Changwon, South Korea
⨯
Sang-Nae Cho,

Affiliations Department of Microbiology, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea
⨯
Sung Jae Shin

* E-mail: sjshin@yuhs.ac

Affiliations Department of Microbiology, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea
⨯

Repeated Aerosolized-Boosting with Gamma-Irradiated Mycobacterium bovis BCG Confers Improved Pulmonary Protection against the Hypervirulent Mycobacterium tuberculosis Strain HN878 in Mice

Seung Bin Cha,
Woo Sik Kim,
Jong-Seok Kim,
Hongmin Kim,
Kee Woong Kwon,
Seung Jung Han,
Seok-Yong Eum,
Sang-Nae Cho,
Sung Jae Shin

Published: October 28, 2015
https://doi.org/10.1371/journal.pone.0141577

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