Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1

Grace Y. Sun; Zihong Chen; Kimberly J. Jasmer; Dennis Y. Chuang; Zezong Gu; Mark Hannink; Agnes Simonyi

doi:10.1371/journal.pone.0141509

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Peer-reviewed

Research Article

Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1

Grace Y. Sun ,

* E-mail: sung@missouri.edu

Affiliations Biochemistry Department, University of Missouri, Columbia, Missouri, United States of America, Interdisciplinary Neuroscience Program, University of Missouri, Columbia, Missouri, United States of America, Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, Missouri, United States of America, Center for Botanical Interaction Studies, University of Missouri, Columbia, Missouri, United States of America
⨯
Zihong Chen,

Affiliations Biochemistry Department, University of Missouri, Columbia, Missouri, United States of America, Center for Botanical Interaction Studies, University of Missouri, Columbia, Missouri, United States of America
⨯
Kimberly J. Jasmer,

Affiliation Division of Biological Sciences, University of Missouri, Columbia, Missouri, United States of America
⨯
Dennis Y. Chuang,

Affiliations Interdisciplinary Neuroscience Program, University of Missouri, Columbia, Missouri, United States of America, Center for Botanical Interaction Studies, University of Missouri, Columbia, Missouri, United States of America
⨯
Zezong Gu,

Affiliations Interdisciplinary Neuroscience Program, University of Missouri, Columbia, Missouri, United States of America, Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, Missouri, United States of America, Center for Botanical Interaction Studies, University of Missouri, Columbia, Missouri, United States of America
⨯
Mark Hannink,

Affiliations Biochemistry Department, University of Missouri, Columbia, Missouri, United States of America, Center for Botanical Interaction Studies, University of Missouri, Columbia, Missouri, United States of America
⨯
Agnes Simonyi

Affiliations Biochemistry Department, University of Missouri, Columbia, Missouri, United States of America, Center for Botanical Interaction Studies, University of Missouri, Columbia, Missouri, United States of America
⨯

Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1

Grace Y. Sun,
Zihong Chen,
Kimberly J. Jasmer,
Dennis Y. Chuang,
Zezong Gu,
Mark Hannink,
Agnes Simonyi

Published: October 27, 2015
https://doi.org/10.1371/journal.pone.0141509

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Microglial cells
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Inflammation
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