Prodrug AST-003 Improves the Therapeutic Index of the Multi-Targeted Tyrosine Kinase Inhibitor Sunitinib

Qiang Huang; Changhua Zhou; Xiao Chen; Bing Dong; Siqi Chen; Ning Zhang; Yawei Liu; Anrong Li; Meicun Yao; Ji Miao; Qing Li; Zhong Wang

doi:10.1371/journal.pone.0141395

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Open Access

Peer-reviewed

Research Article

Prodrug AST-003 Improves the Therapeutic Index of the Multi-Targeted Tyrosine Kinase Inhibitor Sunitinib

Qiang Huang,

Affiliations School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China, Centre for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, China
⨯
Changhua Zhou,

Affiliations School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China, Centre for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, China
⨯
Xiao Chen,

Affiliation School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China
⨯
Bing Dong,

Affiliations School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China, Centre for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, China
⨯
Siqi Chen,

Affiliations School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China, Centre for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, China
⨯
Ning Zhang,

Affiliation Peking University Cancer Hospital, Beijing Institute for Cancer Research, Beijing, China
⨯
Yawei Liu,

Affiliation Health Division of Guard Bureau, General Staff Department of PLA, Beijing, China
⨯
Anrong Li,

Affiliation Ascenta Pharmaceuticals, Guangzhou, Guangdong, P. R. China
⨯
Meicun Yao,

Affiliation School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China
⨯
Ji Miao,

Affiliation School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China
⨯
Qing Li ,

* E-mail: liqing66@mail.sysu.edu.cn (QL); wangzh357@mail.sysue.edu.cn (ZW)

Affiliations School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China, Centre for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, China
⨯
Zhong Wang

* E-mail: liqing66@mail.sysu.edu.cn (QL); wangzh357@mail.sysue.edu.cn (ZW)

Affiliations School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China, Centre for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, China
⨯

Prodrug AST-003 Improves the Therapeutic Index of the Multi-Targeted Tyrosine Kinase Inhibitor Sunitinib

Qiang Huang,
Changhua Zhou,
Xiao Chen,
Bing Dong,
Siqi Chen,
Ning Zhang,
Yawei Liu,
Anrong Li,
Meicun Yao,
Ji Miao

Published: October 29, 2015
https://doi.org/10.1371/journal.pone.0141395

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