Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis

Hiroo Nakashima; Kentaro Oniki; Miki Nishimura; Naoki Ogusu; Masatsugu Shimomasuda; Tatsumasa Ono; Kazuki Matsuda; Norio Yasui-Furukori; Kazuko Nakagawa; Takateru Ishitsu; Junji Saruwatari

doi:10.1371/journal.pone.0141266

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Open Access

Peer-reviewed

Research Article

Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis

Hiroo Nakashima,

Affiliation Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Kentaro Oniki,

Affiliation Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Miki Nishimura,

Affiliation Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Naoki Ogusu,

Affiliation Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Masatsugu Shimomasuda,

Affiliation Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Tatsumasa Ono,

Affiliation Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Kazuki Matsuda,

Affiliation Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Norio Yasui-Furukori,

Affiliation Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
⨯
Kazuko Nakagawa,

Affiliations Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan, Center for Clinical Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Takateru Ishitsu,

Affiliations Kumamoto Saishunso National Hospital, Koshi, Japan, Kumamoto Ezuko Ryoiku Iryo Center, Kumamoto, Japan
⨯
Junji Saruwatari

* E-mail: junsaru@gpo.kumamoto-u.ac.jp

Affiliations Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan, Center for Clinical Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯

Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis

Hiroo Nakashima,
Kentaro Oniki,
Miki Nishimura,
Naoki Ogusu,
Masatsugu Shimomasuda,
Tatsumasa Ono,
Kazuki Matsuda,
Norio Yasui-Furukori,
Kazuko Nakagawa,
Takateru Ishitsu

Published: October 20, 2015
https://doi.org/10.1371/journal.pone.0141266

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