Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1)

• Alexandr N. Simonov,

  Affiliation School of Chemistry, Monash University, Clayton, Victoria, Australia

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• Jessica K. Holien,

  Affiliation ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia

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• Joyee Chun In Yeung,

  Affiliation School of Chemistry, Monash University, Clayton, Victoria, Australia

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• Ann D. Nguyen,

  Affiliation School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

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• C. Jo Corbin,

  Affiliation School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

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• Jie Zheng,

  Affiliation Department of Physiology and Membrane Biology, School of Medicine, University of California Davis, Davis, California, United States of America

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• Vladimir L. Kuznetsov,

  Affiliation Boreskov Institute of Catalysis, Prospekt Lavrentieva 5, Novosibirsk, Russia

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• Richard J. Auchus,

  Affiliation Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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• Alan J. Conley,

  Affiliation School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

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• Alan M. Bond,

  Affiliation School of Chemistry, Monash University, Clayton, Victoria, Australia

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• Michael W. Parker,

  Affiliations ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia

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• Raymond J. Rodgers,

  Affiliation Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia

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• Lisandra L. Martin

  * E-mail: Lisa.Martin@monash.edu

  Affiliation School of Chemistry, Monash University, Clayton, Victoria, Australia

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