Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefrontal Cortex of Spontaneously Hypertensive Rats

Maurício dos Santos Pereira; Matheus Figueiredo Sathler; Thais da Rosa Valli; Richard Souza Marques; Ana Lucia Marques Ventura; Ney Ronner Peccinalli; Mabel Carneiro Fraga; Alex C. Manhães; Regina Kubrusly

doi:10.1371/journal.pone.0141249

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Peer-reviewed

Research Article

Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefrontal Cortex of Spontaneously Hypertensive Rats

Maurício dos Santos Pereira,

Affiliation Laboratório de Neurofarmacologia, Departamento de Fisiologia e Farmacologia, Instituto Biomédico, Universidade Federal Fluminense, Niterói, RJ, Brazil
⨯
Matheus Figueiredo Sathler,

Affiliation Laboratório de Neurofarmacologia, Departamento de Fisiologia e Farmacologia, Instituto Biomédico, Universidade Federal Fluminense, Niterói, RJ, Brazil
⨯
Thais da Rosa Valli,

Affiliation Laboratório de Neurofarmacologia, Departamento de Fisiologia e Farmacologia, Instituto Biomédico, Universidade Federal Fluminense, Niterói, RJ, Brazil
⨯
Richard Souza Marques,

Affiliation Laboratório de Neurofarmacologia, Departamento de Fisiologia e Farmacologia, Instituto Biomédico, Universidade Federal Fluminense, Niterói, RJ, Brazil
⨯
Ana Lucia Marques Ventura,

Affiliation Laboratório de Neuroquímica, Departamento de Neurobiologia, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brazil
⨯
Ney Ronner Peccinalli,

Affiliation Laboratório de Neurofarmacologia, Departamento de Fisiologia e Farmacologia, Instituto Biomédico, Universidade Federal Fluminense, Niterói, RJ, Brazil
⨯
Mabel Carneiro Fraga,

Affiliation Laboratório de Neurofisiologia, Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, Centro Biomédico, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
⨯
Alex C. Manhães,

Affiliation Laboratório de Neurofisiologia, Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, Centro Biomédico, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
⨯
Regina Kubrusly

* E-mail: kubrusly@vm.uff.br

Affiliation Laboratório de Neurofarmacologia, Departamento de Fisiologia e Farmacologia, Instituto Biomédico, Universidade Federal Fluminense, Niterói, RJ, Brazil
⨯

Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefrontal Cortex of Spontaneously Hypertensive Rats

Maurício dos Santos Pereira,
Matheus Figueiredo Sathler,
Thais da Rosa Valli,
Richard Souza Marques,
Ana Lucia Marques Ventura,
Ney Ronner Peccinalli,
Mabel Carneiro Fraga,
Alex C. Manhães,
Regina Kubrusly

Published: October 28, 2015
https://doi.org/10.1371/journal.pone.0141249

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