A Novel Strategy for Detection and Enumeration of Circulating Rare Cell Populations in Metastatic Cancer Patients Using Automated Microfluidic Filtration and Multiplex Immunoassay

Mark Jesus M. Magbanua; Michael Pugia; Jin Sun Lee; Marc Jabon; Victoria Wang; Matthew Gubens; Karen Marfurt; Julia Pence; Harwinder Sidhu; Arejas Uzgiris; Hope S. Rugo; John W. Park

doi:10.1371/journal.pone.0141166

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Open Access

Peer-reviewed

Research Article

A Novel Strategy for Detection and Enumeration of Circulating Rare Cell Populations in Metastatic Cancer Patients Using Automated Microfluidic Filtration and Multiplex Immunoassay

Mark Jesus M. Magbanua ,

Contributed equally to this work with: Mark Jesus M. Magbanua, Michael Pugia

* E-mail: mark.magbanua@ucsf.edu, john.park@ucsf.edu

Affiliation Division of Hematology-Oncology, University of California San Francisco, San Francisco, CA, 94115, United States of America
⨯
Michael Pugia ,

Contributed equally to this work with: Mark Jesus M. Magbanua, Michael Pugia

Affiliation Siemens Healthcare Diagnostics, Elkhart, IN, 46516, United States of America
⨯
Jin Sun Lee,

Affiliation Division of Hematology-Oncology, University of California San Francisco, San Francisco, CA, 94115, United States of America
⨯
Marc Jabon,

Affiliation Division of Hematology-Oncology, University of California San Francisco, San Francisco, CA, 94115, United States of America
⨯
Victoria Wang,

Affiliation Division of Hematology-Oncology, University of California San Francisco, San Francisco, CA, 94115, United States of America
⨯
Matthew Gubens,

Affiliation Division of Hematology-Oncology, University of California San Francisco, San Francisco, CA, 94115, United States of America
⨯
Karen Marfurt,

Affiliation Siemens Healthcare Diagnostics, Elkhart, IN, 46516, United States of America
⨯
Julia Pence,

Affiliation Siemens Healthcare Diagnostics, Elkhart, IN, 46516, United States of America
⨯
Harwinder Sidhu,

Affiliation Siemens Healthcare Diagnostics, Elkhart, IN, 46516, United States of America
⨯
Arejas Uzgiris,

Affiliation Siemens Healthcare Diagnostics, Elkhart, IN, 46516, United States of America
⨯
Hope S. Rugo,

Affiliation Division of Hematology-Oncology, University of California San Francisco, San Francisco, CA, 94115, United States of America
⨯
John W. Park

* E-mail: mark.magbanua@ucsf.edu, john.park@ucsf.edu

Affiliation Division of Hematology-Oncology, University of California San Francisco, San Francisco, CA, 94115, United States of America
⨯

A Novel Strategy for Detection and Enumeration of Circulating Rare Cell Populations in Metastatic Cancer Patients Using Automated Microfluidic Filtration and Multiplex Immunoassay

Mark Jesus M. Magbanua,
Michael Pugia,
Jin Sun Lee,
Marc Jabon,
Victoria Wang,
Matthew Gubens,
Karen Marfurt,
Julia Pence,
Harwinder Sidhu,
Arejas Uzgiris

Published: October 23, 2015
https://doi.org/10.1371/journal.pone.0141166

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