Identification of Small-Molecule Inhibitors against Meso-2, 6-Diaminopimelate Dehydrogenase from Porphyromonas gingivalis

Victoria N. Stone; Hardik I. Parikh; Fadi El-rami; Xiuchun Ge; Weihau Chen; Yan Zhang; Glen E. Kellogg; Ping Xu

doi:10.1371/journal.pone.0141126

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Peer-reviewed

Research Article

Identification of Small-Molecule Inhibitors against Meso-2, 6-Diaminopimelate Dehydrogenase from Porphyromonas gingivalis

Victoria N. Stone,

Affiliations Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Hardik I. Parikh,

Affiliation Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Fadi El-rami,

Affiliations Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Xiuchun Ge,

Affiliation Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Weihau Chen,

Affiliation Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Yan Zhang,

Affiliation Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Glen E. Kellogg,

Affiliations Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, United States of America, Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Ping Xu

* E-mail: pxu@vcu.edu

Affiliations Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America, Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯

Identification of Small-Molecule Inhibitors against Meso-2, 6-Diaminopimelate Dehydrogenase from Porphyromonas gingivalis

Victoria N. Stone,
Hardik I. Parikh,
Fadi El-rami,
Xiuchun Ge,
Weihau Chen,
Yan Zhang,
Glen E. Kellogg,
Ping Xu

Published: November 6, 2015
https://doi.org/10.1371/journal.pone.0141126

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