Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1

Open Access

Peer-reviewed

Research Article

Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H₂S Generation and Endothelin-1

Barbara Renga,

Affiliation Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy
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Sabrina Cipriani,

Affiliation Department of Medicine, University of Perugia, Perugia, Italy
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Adriana Carino,

Affiliation Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy
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Michele Simonetti,

Affiliation Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy
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Angela Zampella,

Affiliation Department of Pharmacy, University of Naples 'Federico II', Naples, Italy
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Stefano Fiorucci

* E-mail: Stefano.Fiorucci@unipg.it

Affiliation Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy
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Methionine
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Phosphorylation
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Portal hypertension
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Cirrhosis
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Mouse models
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Bile
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Gene expression
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Immunoprecipitation
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