Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells

Jarmila Lauková; Alois Kozubík; Jiřina Hofmanová; Jana Nekvindová; Petr Sova; Mary Pat Moyer; Jiří Ehrmann; Alena Hyršlová Vaculová

doi:10.1371/journal.pone.0141020

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Peer-reviewed

Research Article

Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells

Jarmila Lauková,

Affiliations Department of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Brno, Czech Republic, Department of Animal Physiology and Immunology, Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
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Alois Kozubík,

Affiliations Department of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Brno, Czech Republic, Department of Animal Physiology and Immunology, Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
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Jiřina Hofmanová,

Affiliations Department of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Brno, Czech Republic, Department of Animal Physiology and Immunology, Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
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Jana Nekvindová,

Affiliation Institute of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
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Petr Sova,

Affiliation Platinum Pharmaceuticals, a.s., Brno, Czech Republic
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Mary Pat Moyer,

Affiliation INCELL Corporation LLC, San Antonio, Texas, United States of America
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Jiří Ehrmann,

Affiliation Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic
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Alena Hyršlová Vaculová

* E-mail: vaculova@ibp.cz

Affiliation Department of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Brno, Czech Republic
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Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells

Jarmila Lauková,
Alois Kozubík,
Jiřina Hofmanová,
Jana Nekvindová,
Petr Sova,
Mary Pat Moyer,
Jiří Ehrmann,
Alena Hyršlová Vaculová

Published: October 22, 2015
https://doi.org/10.1371/journal.pone.0141020

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