Arsenic Trioxide Reduces Global Histone H4 Acetylation at Lysine 16 through Direct Binding to Histone Acetyltransferase hMOF in Human Cells

Da Liu; Donglu Wu; Linhong Zhao; Yang Yang; Jian Ding; Liguo Dong; Lianghai Hu; Fei Wang; Xiaoming Zhao; Yong Cai; Jingji Jin

doi:10.1371/journal.pone.0141014

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Peer-reviewed

Research Article

Arsenic Trioxide Reduces Global Histone H4 Acetylation at Lysine 16 through Direct Binding to Histone Acetyltransferase hMOF in Human Cells

Da Liu,

Affiliations School of Life Sciences, Jilin University, Changchun, Jilin 130012, China, School of Pharmacy, Changchun University of Traditional Chinese Medicine, Changchun 130117, China
⨯
Donglu Wu,

Affiliation School of Life Sciences, Jilin University, Changchun, Jilin 130012, China
⨯
Linhong Zhao,

Affiliation School of Life Sciences, Jilin University, Changchun, Jilin 130012, China
⨯
Yang Yang,

Affiliation School of Life Sciences, Jilin University, Changchun, Jilin 130012, China
⨯
Jian Ding,

Affiliation School of Life Sciences, Jilin University, Changchun, Jilin 130012, China
⨯
Liguo Dong,

Affiliation School of Life Sciences, Jilin University, Changchun, Jilin 130012, China
⨯
Lianghai Hu,

Affiliations School of Life Sciences, Jilin University, Changchun, Jilin 130012, China, Research Center for Drug Metabolism, School of Life Sciences, Jilin University, Changchun 130012, China
⨯
Fei Wang,

Affiliation School of Life Sciences, Jilin University, Changchun, Jilin 130012, China
⨯
Xiaoming Zhao,

Current address: Central Laboratory, the Third Bethune Hospital of Jilin University, Changchun, Jilin 130033, China

Affiliation School of Life Sciences, Jilin University, Changchun, Jilin 130012, China
⨯
Yong Cai ,

* E-mail: caiyong62@jlu.edu.cn (YC); jjjin@jlu.edu.cn (JJ)

Affiliations School of Life Sciences, Jilin University, Changchun, Jilin 130012, China, National Engineering Laboratory for AIDS Vaccine, Jilin University, Changchun City, Jilin 130012, China, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun City, Jilin 130012, China
⨯
Jingji Jin

* E-mail: caiyong62@jlu.edu.cn (YC); jjjin@jlu.edu.cn (JJ)

Affiliations School of Life Sciences, Jilin University, Changchun, Jilin 130012, China, National Engineering Laboratory for AIDS Vaccine, Jilin University, Changchun City, Jilin 130012, China, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun City, Jilin 130012, China
⨯

Arsenic Trioxide Reduces Global Histone H4 Acetylation at Lysine 16 through Direct Binding to Histone Acetyltransferase hMOF in Human Cells

Da Liu,
Donglu Wu,
Linhong Zhao,
Yang Yang,
Jian Ding,
Liguo Dong,
Lianghai Hu,
Fei Wang,
Xiaoming Zhao,
Yong Cai

Published: October 16, 2015
https://doi.org/10.1371/journal.pone.0141014

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