Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing’s Sarcoma

Sonja J. Gill; Jon Travers; Irina Pshenichnaya; Fiona A. Kogera; Syd Barthorpe; Tatiana Mironenko; Laura Richardson; Cyril H. Benes; Michael R. Stratton; Ultan McDermott; Stephen P. Jackson; Mathew J. Garnett

doi:10.1371/journal.pone.0140988

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Open Access

Peer-reviewed

Research Article

Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing’s Sarcoma

Sonja J. Gill ,

Contributed equally to this work with: Sonja J. Gill, Jon Travers

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Jon Travers ,

Contributed equally to this work with: Sonja J. Gill, Jon Travers

Affiliation The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
⨯
Irina Pshenichnaya,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Fiona A. Kogera,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Syd Barthorpe,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Tatiana Mironenko,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Laura Richardson,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Cyril H. Benes,

Affiliation Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Michael R. Stratton,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Ultan McDermott,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Stephen P. Jackson ,

* E-mail: mg12@sanger.ac.uk (MJG); s.jackson@gurdon.cam.ac.uk (SPJ)

Affiliations Wellcome Trust Sanger Institute, Hinxton, United Kingdom, The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
⨯
Mathew J. Garnett

* E-mail: mg12@sanger.ac.uk (MJG); s.jackson@gurdon.cam.ac.uk (SPJ)

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯

Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing’s Sarcoma

Sonja J. Gill,
Jon Travers,
Irina Pshenichnaya,
Fiona A. Kogera,
Syd Barthorpe,
Tatiana Mironenko,
Laura Richardson,
Cyril H. Benes,
Michael R. Stratton,
Ultan McDermott

Published: October 27, 2015
https://doi.org/10.1371/journal.pone.0140988

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