Creation of Functional Viruses from Non-Functional cDNA Clones Obtained from an RNA Virus Population by the Use of Ancestral Reconstruction

• Ulrik Fahnøe,

  Affiliations DTU National Veterinary Institute, Technical University of Denmark, Lindholm, Kalvehave, Denmark, Center for Biological Sequence Analysis, DTU Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark

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• Anders Gorm Pedersen,

  Affiliation Center for Biological Sequence Analysis, DTU Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark

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• Carolin Dräger,

  Affiliation Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany

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• Richard J Orton,

  Affiliations Institute of Biodiversity, Animal Health, and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, MRC–University of Glasgow Centre for Virus Research, Institute of Infection, Inflammation and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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• Sandra Blome,

  Affiliation Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany

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• Dirk Höper,

  Affiliation Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany

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• Martin Beer,

  Affiliation Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany

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• Thomas Bruun Rasmussen

  * E-mail: tbrur@vet.dtu.dk

  Affiliation DTU National Veterinary Institute, Technical University of Denmark, Lindholm, Kalvehave, Denmark

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