Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo

Ioannis Kokkinopoulos; Hidekazu Ishida; Rie Saba; Prashant Ruchaya; Claudia Cabrera; Monika Struebig; Michael Barnes; Anna Terry; Masahiro Kaneko; Yasunori Shintani; Steven Coppen; Hidetaka Shiratori; Torath Ameen; Charles Mein; Hiroshi Hamada; Ken Suzuki; Kenta Yashiro

doi:10.1371/journal.pone.0140831

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Research Article

Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo

Ioannis Kokkinopoulos,

Affiliation Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
⨯
Hidekazu Ishida,

Affiliation Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
⨯
Rie Saba,

Affiliation Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
⨯
Prashant Ruchaya,

Affiliations Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, Physiology and Pathology, University of São Paulo State – UNESP, Araraquara School of Dentistry, Araraquara, São Paulo, Brazil
⨯
Claudia Cabrera,

Affiliations Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
⨯
Monika Struebig,

Affiliation Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
⨯
Michael Barnes,

Affiliation Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
⨯
Anna Terry,

Affiliation Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
⨯
Masahiro Kaneko,

Affiliation Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
⨯
Yasunori Shintani,

Affiliation Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
⨯
Steven Coppen,

Affiliation Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
⨯
Hidetaka Shiratori,

Affiliation Department of Developmental Genetics, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan
⨯
Torath Ameen,

Affiliation Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
⨯
Charles Mein,

Affiliation Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
⨯
Hiroshi Hamada,

Affiliation Department of Developmental Genetics, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan
⨯
Ken Suzuki,

Affiliation Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
⨯
[ ... ],
Kenta Yashiro

* E-mail: k.yashiro@qmul.ac.uk

Affiliation Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
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Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo

Ioannis Kokkinopoulos,
Hidekazu Ishida,
Rie Saba,
Prashant Ruchaya,
Claudia Cabrera,
Monika Struebig,
Michael Barnes,
Anna Terry,
Masahiro Kaneko,
Yasunori Shintani

Published: October 15, 2015
https://doi.org/10.1371/journal.pone.0140831

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Cell differentiation
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Cardiomyocytes
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