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Open Access
Peer-reviewed
Research Article
Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction
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Paul L. Klarenbeek,
Affiliations Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Clinical Immunology and Rheumatology, Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Laboratory for Genome Analysis, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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Marieke E. Doorenspleet,
Affiliations Department of Clinical Immunology and Rheumatology, Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Laboratory for Genome Analysis, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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Rebecca E. E. Esveldt,
Affiliation Department of Clinical Immunology and Rheumatology, Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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Barbera D. C. van Schaik,
Affiliation Department of Clinical Epidemiology, Biostatistics and Bioinformatics, University of Amsterdam, Amsterdam, The Netherlands
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Neubury Lardy,
Affiliation Department of Immunogenetics, Sanquin Diagnostic Services, Amsterdam, The Netherlands
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Antoine H. C. van Kampen,
Affiliation Department of Clinical Epidemiology, Biostatistics and Bioinformatics, University of Amsterdam, Amsterdam, The Netherlands
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Paul P. Tak,
Current address: GlaxoSmithKline, Stevenage, United Kingdom; University of Cambridge, Cambridge, United Kingdom
Affiliation Department of Clinical Immunology and Rheumatology, Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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Robert M. Plenge,
Current address: Merck and Co., Boston, Massachusetts, United States of America
Affiliations Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Frank Baas,
Affiliation Laboratory for Genome Analysis, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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Paul I. W. de Bakker ,
Contributed equally to this work with: Paul I. W. de Bakker, Niek de Vries
* E-mail: pdebakker@umcutrecht.nl
Affiliations Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Epidemiology, University Medical Center, Utrecht, The Netherlands, Department of Medical Genetics, University Medical Center, Utrecht, The Netherlands
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Niek de Vries
Contributed equally to this work with: Paul I. W. de Bakker, Niek de Vries
Affiliation Department of Clinical Immunology and Rheumatology, Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction
- Paul L. Klarenbeek,
- Marieke E. Doorenspleet,
- Rebecca E. E. Esveldt,
- Barbera D. C. van Schaik,
- Neubury Lardy,
- Antoine H. C. van Kampen,
- Paul P. Tak,
- Robert M. Plenge,
- Frank Baas,
- Paul I. W. de Bakker
- Published: October 30, 2015
- https://doi.org/10.1371/journal.pone.0140815