Ulipristal Acetate Inhibits Progesterone Receptor Isoform A-Mediated Human Breast Cancer Proliferation and BCl2-L1 Expression

Nathalie Esber; Florian Le Billan; Michèle Resche-Rigon; Hugues Loosfelt; Marc Lombès; Nathalie Chabbert-Buffet

doi:10.1371/journal.pone.0140795

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Research Article

Ulipristal Acetate Inhibits Progesterone Receptor Isoform A-Mediated Human Breast Cancer Proliferation and BCl₂-L₁ Expression

Nathalie Esber,

Affiliations Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche-Scientifique 1185, Faculté de Médecine Paris Sud, Le Kremlin-Bicêtre, France, Université Paris-Sud, Faculté de Médecine Paris Sud, Unité Mixte de Recherche-Scientifique 1185, Le Kremlin-Bicêtre, France, HRA-Pharma, Paris, France
⨯
Florian Le Billan,

Affiliations Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche-Scientifique 1185, Faculté de Médecine Paris Sud, Le Kremlin-Bicêtre, France, Université Paris-Sud, Faculté de Médecine Paris Sud, Unité Mixte de Recherche-Scientifique 1185, Le Kremlin-Bicêtre, France
⨯
Michèle Resche-Rigon,

Affiliation HRA-Pharma, Paris, France
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Hugues Loosfelt,

Affiliations Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche-Scientifique 1185, Faculté de Médecine Paris Sud, Le Kremlin-Bicêtre, France, Université Paris-Sud, Faculté de Médecine Paris Sud, Unité Mixte de Recherche-Scientifique 1185, Le Kremlin-Bicêtre, France
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Marc Lombès,

Affiliations Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche-Scientifique 1185, Faculté de Médecine Paris Sud, Le Kremlin-Bicêtre, France, Université Paris-Sud, Faculté de Médecine Paris Sud, Unité Mixte de Recherche-Scientifique 1185, Le Kremlin-Bicêtre, France, Service d’Endocrinologie et des Maladies de la Reproduction, assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin Bicêtre, France
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Nathalie Chabbert-Buffet

* E-mail: nathalie.chabbert-buffet@tnn.aphp.fr

Affiliations Service de Gynécologie Obstétrique Médecine de la Reproduction, Hôpitaux Universitaires Est Parisien site Tenon, AP-HP, Paris, France, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche-Scientifique 938, Centre de Recherche Saint Antoine, Université Pierre et Marie Curie, Paris, France
⨯

Ulipristal Acetate Inhibits Progesterone Receptor Isoform A-Mediated Human Breast Cancer Proliferation and BCl₂-L₁ Expression

Nathalie Esber,
Florian Le Billan,
Michèle Resche-Rigon,
Hugues Loosfelt,
Marc Lombès,
Nathalie Chabbert-Buffet

Published: October 16, 2015
https://doi.org/10.1371/journal.pone.0140795

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Cell proliferation
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Breast cancer
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Gene expression
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Progesterone
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Gene regulation
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Estrogens
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