Missense Mutations in LRP5 Associated with High Bone Mass Protect the Mouse Skeleton from Disuse- and Ovariectomy-Induced Osteopenia

• Paul J. Niziolek,

  Affiliations Department of Anatomy & Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States of America

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• Whitney Bullock,

  Affiliation Department of Anatomy & Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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• Matthew L. Warman,

  Affiliations Department of Orthopaedic Surgery, Children’s Hospital, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Massachusetts, United States of America

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• Alexander G. Robling

  * E-mail: arobling@iupui.edu

  Affiliations Department of Anatomy & Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Biomedical Engineering, Indiana University–Purdue University at Indianapolis (IUPUI), Indianapolis, Indiana, United States of America, Richard L. Roudebush VA Medical Center, Indianapolis, Indiana, United States of America

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