Potent Sensitisation of Cancer Cells to Anticancer Drugs by a Quadruple Mutant of the Human Deoxycytidine Kinase

Safiatou T. Coulibaly; Paola Rossolillo; Flore Winter; Franziska K. Kretzschmar; Mélanie Brayé; Darren P. Martin; Daniela Lener; Matteo Negroni

doi:10.1371/journal.pone.0140741

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Open Access

Peer-reviewed

Research Article

Potent Sensitisation of Cancer Cells to Anticancer Drugs by a Quadruple Mutant of the Human Deoxycytidine Kinase

Safiatou T. Coulibaly ,

Contributed equally to this work with: Safiatou T. Coulibaly, Paola Rossolillo

Affiliation Architecture et Réactivité de l'ARN, CNRS, IBMC, Université de Strasbourg, 15 rue René Descartes, 67084 Strasbourg, Cedex, France
⨯
Paola Rossolillo ,

Contributed equally to this work with: Safiatou T. Coulibaly, Paola Rossolillo

Affiliation Architecture et Réactivité de l'ARN, CNRS, IBMC, Université de Strasbourg, 15 rue René Descartes, 67084 Strasbourg, Cedex, France
⨯
Flore Winter,

Affiliation Architecture et Réactivité de l'ARN, CNRS, IBMC, Université de Strasbourg, 15 rue René Descartes, 67084 Strasbourg, Cedex, France
⨯
Franziska K. Kretzschmar,

Affiliation Architecture et Réactivité de l'ARN, CNRS, IBMC, Université de Strasbourg, 15 rue René Descartes, 67084 Strasbourg, Cedex, France
⨯
Mélanie Brayé,

Affiliation Architecture et Réactivité de l'ARN, CNRS, IBMC, Université de Strasbourg, 15 rue René Descartes, 67084 Strasbourg, Cedex, France
⨯
Darren P. Martin,

Affiliations Centre for High-Performance Computing, Rosebank, Cape Town, South Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
⨯
Daniela Lener,

Affiliation Architecture et Réactivité de l'ARN, CNRS, IBMC, Université de Strasbourg, 15 rue René Descartes, 67084 Strasbourg, Cedex, France
⨯
Matteo Negroni

* E-mail: m.negroni@ibmc-cnrs.unistra.fr

Affiliation Architecture et Réactivité de l'ARN, CNRS, IBMC, Université de Strasbourg, 15 rue René Descartes, 67084 Strasbourg, Cedex, France
⨯

Potent Sensitisation of Cancer Cells to Anticancer Drugs by a Quadruple Mutant of the Human Deoxycytidine Kinase

Safiatou T. Coulibaly,
Paola Rossolillo,
Flore Winter,
Franziska K. Kretzschmar,
Mélanie Brayé,
Darren P. Martin,
Daniela Lener,
Matteo Negroni

Published: October 20, 2015
https://doi.org/10.1371/journal.pone.0140741

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