Inhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer’s Disease Cell Model

Huiyu Liang; Yusheng Shi; Zhewen Kou; Yonghua Peng; Wenjun Chen; Xiaowen Li; Shuji Li; Ying Wang; Fang Wang; Xingmei Zhang

doi:10.1371/journal.pone.0140733

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Open Access

Peer-reviewed

Research Article

Inhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer’s Disease Cell Model

Huiyu Liang ,

Contributed equally to this work with: Huiyu Liang, Yusheng Shi

Current address: Nanmatou Community Health Service Centre, Pudong District, Shanghai, China

Affiliation Key Laboratory of Psychiatric Disorders of Guangdong Province, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
⨯
Yusheng Shi ,

Contributed equally to this work with: Huiyu Liang, Yusheng Shi

Affiliation Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⨯
Zhewen Kou,

Affiliation Key Laboratory of Psychiatric Disorders of Guangdong Province, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
⨯
Yonghua Peng,

Affiliation Key Laboratory of Psychiatric Disorders of Guangdong Province, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
⨯
Wenjun Chen,

Affiliation Key Laboratory of Psychiatric Disorders of Guangdong Province, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
⨯
Xiaowen Li,

Affiliation Key Laboratory of Psychiatric Disorders of Guangdong Province, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
⨯
Shuji Li,

Affiliation Key Laboratory of Psychiatric Disorders of Guangdong Province, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
⨯
Ying Wang,

Affiliation Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
⨯
Fang Wang,

Affiliation Key Laboratory of Psychiatric Disorders of Guangdong Province, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
⨯
Xingmei Zhang

* E-mail: zhangxm@smu.edu.cn

Affiliation Key Laboratory of Psychiatric Disorders of Guangdong Province, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
⨯

Inhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer’s Disease Cell Model

Huiyu Liang,
Yusheng Shi,
Zhewen Kou,
Yonghua Peng,
Wenjun Chen,
Xiaowen Li,
Shuji Li,
Ying Wang,
Fang Wang,
Xingmei Zhang

Published: October 16, 2015
https://doi.org/10.1371/journal.pone.0140733

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