TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway

Brian Tomkowicz; Eileen Walsh; Adam Cotty; Raluca Verona; Nina Sabins; Fred Kaplan; Sandy Santulli-Marotto; Chen-Ni Chin; Jill Mooney; Russell B. Lingham; Michael Naso; Timothy McCabe

doi:10.1371/journal.pone.0140694

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Open Access

Peer-reviewed

Research Article

TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway

Brian Tomkowicz ,

* E-mail: btomkowi@its.jnj.com (BT); tmccabe1@its.jnj.com (TM)

Affiliation Janssen BioTherapeutics, 1400 McKean Road, Spring House, PA 19477, United States of America
⨯
Eileen Walsh,

Affiliation Janssen BioTherapeutics, 1400 McKean Road, Spring House, PA 19477, United States of America
⨯
Adam Cotty,

Affiliation Janssen BioTherapeutics, 1400 McKean Road, Spring House, PA 19477, United States of America
⨯
Raluca Verona,

Affiliation Janssen BioTherapeutics, 1400 McKean Road, Spring House, PA 19477, United States of America
⨯
Nina Sabins,

Affiliation Janssen BioTherapeutics, 1400 McKean Road, Spring House, PA 19477, United States of America
⨯
Fred Kaplan,

Affiliation Janssen BioTherapeutics, 1400 McKean Road, Spring House, PA 19477, United States of America
⨯
Sandy Santulli-Marotto,

Affiliation Janssen BioTherapeutics, 1400 McKean Road, Spring House, PA 19477, United States of America
⨯
Chen-Ni Chin,

Affiliation Janssen BioTherapeutics, 1400 McKean Road, Spring House, PA 19477, United States of America
⨯
Jill Mooney,

Affiliation Janssen BioTherapeutics, 1400 McKean Road, Spring House, PA 19477, United States of America
⨯
Russell B. Lingham,

Affiliation Janssen BioTherapeutics, 1400 McKean Road, Spring House, PA 19477, United States of America
⨯
Michael Naso,

Affiliation Janssen BioTherapeutics, 1400 McKean Road, Spring House, PA 19477, United States of America
⨯
Timothy McCabe

* E-mail: btomkowi@its.jnj.com (BT); tmccabe1@its.jnj.com (TM)

Affiliation Janssen BioTherapeutics, 1400 McKean Road, Spring House, PA 19477, United States of America
⨯

TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway

Brian Tomkowicz,
Eileen Walsh,
Adam Cotty,
Raluca Verona,
Nina Sabins,
Fred Kaplan,
Sandy Santulli-Marotto,
Chen-Ni Chin,
Jill Mooney,
Russell B. Lingham

Published: October 22, 2015
https://doi.org/10.1371/journal.pone.0140694

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