Three-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic Leukemia

Allison Bruce; Rebecca Evans; Ryan Mezan; Lin Shi; Blake S. Moses; Karen H. Martin; Laura F. Gibson; Yong Yang

doi:10.1371/journal.pone.0140506

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Peer-reviewed

Research Article

Three-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic Leukemia

Allison Bruce,

Affiliation Department of Chemical Engineering, West Virginia University, Morgantown, West Virginia, United States of America
⨯
Rebecca Evans,

Affiliation Alexander B. Osborn Hematopoietic Malignancy and Transplantation Program, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, United States of America
⨯
Ryan Mezan,

Affiliation Department of Chemical Engineering, West Virginia University, Morgantown, West Virginia, United States of America
⨯
Lin Shi,

Affiliation Department of Chemical Engineering, West Virginia University, Morgantown, West Virginia, United States of America
⨯
Blake S. Moses,

Affiliation Alexander B. Osborn Hematopoietic Malignancy and Transplantation Program, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, United States of America
⨯
Karen H. Martin,

Affiliation Department of Neurobiology and Anatomy, West Virginia University, Morgantown, West Virginia, United States of America
⨯
Laura F. Gibson ,

* E-mail: yong.yang@mail.wvu.edu (YY); lgibson@hsc.wvu.edu (LFG)

Affiliations Alexander B. Osborn Hematopoietic Malignancy and Transplantation Program, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, United States of America, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia, United States of America
⨯
Yong Yang

* E-mail: yong.yang@mail.wvu.edu (YY); lgibson@hsc.wvu.edu (LFG)

Affiliation Department of Chemical Engineering, West Virginia University, Morgantown, West Virginia, United States of America
⨯

Three-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic Leukemia

Allison Bruce,
Rebecca Evans,
Ryan Mezan,
Lin Shi,
Blake S. Moses,
Karen H. Martin,
Laura F. Gibson,
Yong Yang

Published: October 21, 2015
https://doi.org/10.1371/journal.pone.0140506

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Microfluidics
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Collagens
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Bone marrow cells
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Extracellular matrix
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