Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium

• Joshua C. Bis ,

  Contributed equally to this work with: Joshua C. Bis, Colleen Sitlani, Ryan Irvin, Christy L. Avery, Eric A. Whitsel, Bruce M. Psaty, Donna Arnett

  Affiliation Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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• Colleen Sitlani ,

  Contributed equally to this work with: Joshua C. Bis, Colleen Sitlani, Ryan Irvin, Christy L. Avery, Eric A. Whitsel, Bruce M. Psaty, Donna Arnett

  Affiliation Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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• Ryan Irvin ,

  Contributed equally to this work with: Joshua C. Bis, Colleen Sitlani, Ryan Irvin, Christy L. Avery, Eric A. Whitsel, Bruce M. Psaty, Donna Arnett

  Affiliation Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Christy L. Avery ,

  Contributed equally to this work with: Joshua C. Bis, Colleen Sitlani, Ryan Irvin, Christy L. Avery, Eric A. Whitsel, Bruce M. Psaty, Donna Arnett

  Affiliation Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America

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• Albert Vernon Smith,

  Affiliations Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

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• Fangui Sun,

  Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

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• Daniel S. Evans,

  Affiliation California Pacific Medical Center Research Institute, San Francisco, California, United States of America

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• Solomon K. Musani,

  Affiliation Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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• Xiaohui Li,

  Affiliations Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, United States of America

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• Stella Trompet,

  Affiliations Department of Cardiology, Leiden University Medical Center, The Netherlands, Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands

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• Bouwe P. Krijthe,

  Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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• Tamara B. Harris,

  Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

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• P. Miguel Quibrera,

  Affiliation Collaborative Studies Coordinating Center, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America

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• Jennifer A. Brody,

  Affiliation Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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• Serkalem Demissie,

  Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

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• Barry R. Davis,

  Affiliation Department of Biostatistics, University of Texas School of Public Health, Houston, Texas, United States of America

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• Kerri L. Wiggins,

  Affiliation Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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• Gregory J. Tranah,

  Affiliations California Pacific Medical Center Research Institute, San Francisco, California, United States of America, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America

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• Leslie A. Lange,

  Affiliation Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, 27599, United States of America

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• Nona Sotoodehnia,

  Affiliations Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Cardiology Division, University of Washington, Seattle, Washington, United States of America

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• David J. Stott,

  Affiliation Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom

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• Oscar H. Franco,

  Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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• Lenore J. Launer,

  Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

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• Til Stürmer,

  Affiliations Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America, University of North Carolina—GSK Center of Excellence in Pharmacoepidemiology, Chapel Hill, North Carolina, United States of America

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• Kent D. Taylor,

  Affiliations Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, United States of America

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• L. Adrienne Cupples,

  Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, The Framingham Heart Study, Framingham, Massachusetts, United States of America

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• John H. Eckfeldt,

  Affiliation Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, United States of America

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• Nicholas L. Smith,

  Affiliations Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Seattle Epidemiologic Research and Information Center of the Department of Veterans Affairs Office of Research and Development, Seattle, Washington, United States of America, Group Health Research Institute, Group Health, Seattle, Washington, United States of America

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• Yongmei Liu,

  Affiliation Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina, United States of America

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• James G. Wilson,

  Affiliation Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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• Susan R. Heckbert,

  Affiliations Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health, Seattle, Washington, United States of America

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• Brendan M. Buckley,

  Affiliation Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland

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• M. Arfan Ikram,

  Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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• Eric Boerwinkle,

  Affiliation Institute for Molecular Medicine, University of Texas Health Science Center, Houston, Texas, United States of America

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• Yii-Der Ida Chen,

  Affiliations Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, United States of America

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• Anton J. M. de Craen,

  Affiliation Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands

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• Andre G. Uitterlinden,

  Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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• Jerome I. Rotter,

  Affiliations Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, United States of America

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• Ian Ford,

  Affiliation Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom

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• Albert Hofman,

  Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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• Naveed Sattar,

  Affiliation BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, United Kingdom

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• P. Eline Slagboom,

  Affiliation Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

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• Rudi G. J. Westendorp,

  Affiliation Faculty of Health and Medical Sciences, Department of Public Health, University of Copenhagen, Copenhagen, Denmark

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• Vilmundur Gudnason,

  Affiliations Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

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• Ramachandran S. Vasan,

  Affiliations The Framingham Heart Study, Framingham, Massachusetts, United States of America, Boston University School of Medicine, Boston, Massachusetts, United States of America, Boston University School of Public Health, Boston, Massachusetts, United States of America

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• Thomas Lumley,

  Affiliation Department of Statistics, University of Auckland, Auckland, New Zealand

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• Steven R. Cummings,

  Affiliation California Pacific Medical Center Research Institute, San Francisco, California, United States of America

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• Herman A. Taylor Jr,

  Affiliation Department of Medicine, Morehouse School of Medicine, Atlanta, Georgia, United States of America

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• Wendy Post,

  Affiliation Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

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• J. Wouter Jukema,

  Affiliation Department of Cardiology, Leiden University Medical Center, The Netherlands

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• Bruno H. Stricker,

  Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Inspectorate for Health Care, the Hague, The Netherlands

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• Eric A. Whitsel ,

  Contributed equally to this work with: Joshua C. Bis, Colleen Sitlani, Ryan Irvin, Christy L. Avery, Eric A. Whitsel, Bruce M. Psaty, Donna Arnett

  Affiliations Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina United States of America

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• Bruce M. Psaty ,

  Contributed equally to this work with: Joshua C. Bis, Colleen Sitlani, Ryan Irvin, Christy L. Avery, Eric A. Whitsel, Bruce M. Psaty, Donna Arnett

  * E-mail: psaty@uw.edu

  Affiliations Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Department of Health Services, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health, Seattle, Washington, United States of America

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•  [ ... ],
• Donna Arnett

  Contributed equally to this work with: Joshua C. Bis, Colleen Sitlani, Ryan Irvin, Christy L. Avery, Eric A. Whitsel, Bruce M. Psaty, Donna Arnett

  Affiliation Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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