Large-Scale Purification of r28M: A Bispecific scFv Antibody Targeting Human Melanoma Produced in Transgenic Cattle

Katrin Spiesberger; Florian Paulfranz; Anton Egger; Judith Reiser; Claus Vogl; Judith Rudolf-Scholik; Corina Mayrhofer; Ludger Grosse-Hovest; Gottfried Brem

doi:10.1371/journal.pone.0140471

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Open Access

Peer-reviewed

Research Article

Large-Scale Purification of r28M: A Bispecific scFv Antibody Targeting Human Melanoma Produced in Transgenic Cattle

Katrin Spiesberger ,

* E-mail: katrin.spiesberger@vetmeduni.ac.at

Affiliations Department of Biomedical Sciences, Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria, Christian Doppler Laboratory for Innovative Immunotherapy, University of Veterinary Medicine Vienna, Vienna, Austria
⨯
Florian Paulfranz,

Affiliation Christian Doppler Laboratory for Innovative Immunotherapy, University of Veterinary Medicine Vienna, Vienna, Austria
⨯
Anton Egger,

Affiliation Christian Doppler Laboratory for Innovative Immunotherapy, University of Veterinary Medicine Vienna, Vienna, Austria
⨯
Judith Reiser,

Affiliation Christian Doppler Laboratory for Innovative Immunotherapy, University of Veterinary Medicine Vienna, Vienna, Austria
⨯
Claus Vogl,

Affiliation Department of Biomedical Sciences, Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria
⨯
Judith Rudolf-Scholik,

Affiliation Christian Doppler Laboratory for Innovative Immunotherapy, University of Veterinary Medicine Vienna, Vienna, Austria
⨯
Corina Mayrhofer,

Affiliations Department of Biomedical Sciences, Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria, Department of Agrobiotechnology (IFA Tulln), Institute of Biotechnology in Animal Production, University of Natural Resources and Applied Life Sciences Vienna, Tulln, Austria
⨯
Ludger Grosse-Hovest,

Affiliation Department of Immunology, Institute for Cell Biology, University of Tübingen, Tübingen, Germany
⨯
Gottfried Brem

Affiliations Department of Biomedical Sciences, Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria, Christian Doppler Laboratory for Innovative Immunotherapy, University of Veterinary Medicine Vienna, Vienna, Austria, Department of Agrobiotechnology (IFA Tulln), Institute of Biotechnology in Animal Production, University of Natural Resources and Applied Life Sciences Vienna, Tulln, Austria
⨯

Large-Scale Purification of r28M: A Bispecific scFv Antibody Targeting Human Melanoma Produced in Transgenic Cattle

Katrin Spiesberger,
Florian Paulfranz,
Anton Egger,
Judith Reiser,
Claus Vogl,
Judith Rudolf-Scholik,
Corina Mayrhofer,
Ludger Grosse-Hovest,
Gottfried Brem

Published: October 15, 2015
https://doi.org/10.1371/journal.pone.0140471

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