Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture

Kenneth R. Muir; Maria João Lima; Hilary M. Docherty; Neil W. A. McGowan; Shareen Forbes; Yves Heremans; Stuart J. Forbes; Harry Heimberg; John Casey; Kevin Docherty

doi:10.1371/journal.pone.0140352

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Peer-reviewed

Research Article

Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture

Kenneth R. Muir ,

Contributed equally to this work with: Kenneth R. Muir, Maria João Lima

Affiliation School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom
⨯
Maria João Lima ,

Contributed equally to this work with: Kenneth R. Muir, Maria João Lima

Affiliation School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom
⨯
Hilary M. Docherty,

Affiliation School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom
⨯
Neil W. A. McGowan,

Affiliation Department of Surgery, University of Edinburgh, Edinburgh Royal Infirmary, Edinburgh, United Kingdom
⨯
Shareen Forbes,

Affiliation Endocrinology Unit, University/BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
⨯
Yves Heremans,

Affiliation Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
⨯
Stuart J. Forbes,

Affiliation MRC Centre for Regenerative Medicine, SCRM Building, The University of Edinburgh, Edinburgh, United Kingdom
⨯
Harry Heimberg,

Affiliation Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
⨯
John Casey,

Affiliation Department of Surgery, University of Edinburgh, Edinburgh Royal Infirmary, Edinburgh, United Kingdom
⨯
Kevin Docherty

* E-mail: k.docherty@abdn.ac.uk

Affiliation School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom
⨯

Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture

Kenneth R. Muir,
Maria João Lima,
Hilary M. Docherty,
Neil W. A. McGowan,
Shareen Forbes,
Yves Heremans,
Stuart J. Forbes,
Harry Heimberg,
John Casey,
Kevin Docherty

Published: October 12, 2015
https://doi.org/10.1371/journal.pone.0140352

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