Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere Shortening and Cellular Senescence

Ryusaku Matsumoto; Hidenori Fukuoka; Genzo Iguchi; Yukiko Odake; Kenichi Yoshida; Hironori Bando; Kentaro Suda; Hitoshi Nishizawa; Michiko Takahashi; Shozo Yamada; Wataru Ogawa; Yutaka Takahashi

doi:10.1371/journal.pone.0140189

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Peer-reviewed

Research Article

Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere Shortening and Cellular Senescence

Ryusaku Matsumoto,

Affiliation Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
⨯
Hidenori Fukuoka,

Affiliation Division of Diabetes and Endocrinology, Kobe University Hospital, Kobe, Hyogo, Japan
⨯
Genzo Iguchi,

Affiliation Division of Diabetes and Endocrinology, Kobe University Hospital, Kobe, Hyogo, Japan
⨯
Yukiko Odake,

Affiliation Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
⨯
Kenichi Yoshida,

Affiliation Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
⨯
Hironori Bando,

Affiliation Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
⨯
Kentaro Suda,

Affiliation Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
⨯
Hitoshi Nishizawa,

Affiliation Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
⨯
Michiko Takahashi,

Affiliation Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
⨯
Shozo Yamada,

Affiliation Department of Hypothalamic and Pituitary Surgery, Toranomon Hospital, Minato-ku, Tokyo, Japan
⨯
Wataru Ogawa,

Affiliation Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
⨯
Yutaka Takahashi

* E-mail: takahash@med.kobe-u.ac.jp

Affiliation Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
⨯

Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere Shortening and Cellular Senescence

Ryusaku Matsumoto,
Hidenori Fukuoka,
Genzo Iguchi,
Yukiko Odake,
Kenichi Yoshida,
Hironori Bando,
Kentaro Suda,
Hitoshi Nishizawa,
Michiko Takahashi,
Shozo Yamada

Published: October 8, 2015
https://doi.org/10.1371/journal.pone.0140189

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Telomeres
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Telomere length
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Acromegaly
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Fibroblasts
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Diabetes mellitus
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Polymerase chain reaction
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