In-Depth, Label-Free Analysis of the Erythrocyte Cytoplasmic Proteome in Diamond Blackfan Anemia Identifies a Unique Inflammatory Signature

Esther N. Pesciotta; Ho-Sun Lam; Andrew Kossenkov; Jingping Ge; Louise C. Showe; Philip J. Mason; Monica Bessler; David W. Speicher

doi:10.1371/journal.pone.0140036

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Peer-reviewed

Research Article

In-Depth, Label-Free Analysis of the Erythrocyte Cytoplasmic Proteome in Diamond Blackfan Anemia Identifies a Unique Inflammatory Signature

Esther N. Pesciotta,

Affiliations Division of Hematology, Department of Pediatrics, Children’s Hospital of Philadelphia, University of Pennsylvania, 3615 Civic Center Blvd Philadelphia, PA, 19104, United States of America, Center for Systems and Computational Biology and Molecular and Cellular Oncogenesis Program, The Wistar Institute, 3601 Spruce St. Philadelphia, PA, 19104, United States of America
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Ho-Sun Lam,

Affiliation Division of Hematology, Department of Pediatrics, Children’s Hospital of Philadelphia, University of Pennsylvania, 3615 Civic Center Blvd Philadelphia, PA, 19104, United States of America
⨯
Andrew Kossenkov,

Affiliation Center for Systems and Computational Biology and Molecular and Cellular Oncogenesis Program, The Wistar Institute, 3601 Spruce St. Philadelphia, PA, 19104, United States of America
⨯
Jingping Ge,

Affiliation Division of Hematology, Department of Pediatrics, Children’s Hospital of Philadelphia, University of Pennsylvania, 3615 Civic Center Blvd Philadelphia, PA, 19104, United States of America
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Louise C. Showe,

Affiliation Center for Systems and Computational Biology and Molecular and Cellular Oncogenesis Program, The Wistar Institute, 3601 Spruce St. Philadelphia, PA, 19104, United States of America
⨯
Philip J. Mason,

Affiliation Division of Hematology, Department of Pediatrics, Children’s Hospital of Philadelphia, University of Pennsylvania, 3615 Civic Center Blvd Philadelphia, PA, 19104, United States of America
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Monica Bessler,

Affiliations Division of Hematology, Department of Pediatrics, Children’s Hospital of Philadelphia, University of Pennsylvania, 3615 Civic Center Blvd Philadelphia, PA, 19104, United States of America, Division of Hematology/Oncology, Department of Internal Medicine, University of Pennsylvania, 3620 Hamilton Walk Philadelphia, PA, 19104, United States of America
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David W. Speicher

* E-mail: speicher@wistar.org

Affiliation Center for Systems and Computational Biology and Molecular and Cellular Oncogenesis Program, The Wistar Institute, 3601 Spruce St. Philadelphia, PA, 19104, United States of America
⨯

In-Depth, Label-Free Analysis of the Erythrocyte Cytoplasmic Proteome in Diamond Blackfan Anemia Identifies a Unique Inflammatory Signature

Esther N. Pesciotta,
Ho-Sun Lam,
Andrew Kossenkov,
Jingping Ge,
Louise C. Showe,
Philip J. Mason,
Monica Bessler,
David W. Speicher

Published: October 16, 2015
https://doi.org/10.1371/journal.pone.0140036

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