The Effect of Statins on Blood Gene Expression in COPD

Ma’en Obeidat; Nick Fishbane; Yunlong Nie; Virginia Chen; Zsuzsanna Hollander; Scott J. Tebbutt; Yohan Bossé; Raymond T. Ng; Bruce E. Miller; Bruce McManus; Stephen Rennard; Peter D. Paré; Don D. Sin

doi:10.1371/journal.pone.0140022

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Open Access

Peer-reviewed

Research Article

The Effect of Statins on Blood Gene Expression in COPD

Ma’en Obeidat,

Affiliation The University of British Columbia Centre for Heart Lung Innovation, St Paul’s Hospital, Vancouver, BC, Canada
⨯
Nick Fishbane,

Affiliation The University of British Columbia Centre for Heart Lung Innovation, St Paul’s Hospital, Vancouver, BC, Canada
⨯
Yunlong Nie,

Affiliation The University of British Columbia Centre for Heart Lung Innovation, St Paul’s Hospital, Vancouver, BC, Canada
⨯
Virginia Chen,

Affiliation Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, BC, Canada
⨯
Zsuzsanna Hollander,

Affiliation Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, BC, Canada
⨯
Scott J. Tebbutt,

Affiliations The University of British Columbia Centre for Heart Lung Innovation, St Paul’s Hospital, Vancouver, BC, Canada, Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, BC, Canada, Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
⨯
Yohan Bossé,

Affiliation Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec, Canada
⨯
Raymond T. Ng,

Affiliation Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, BC, Canada
⨯
Bruce E. Miller,

Affiliation Respiratory Therapy Area Unit, GlaxoSmithKline R&D, King of Prussia, Pennsylvania, United States of America
⨯
Bruce McManus,

Affiliations The University of British Columbia Centre for Heart Lung Innovation, St Paul’s Hospital, Vancouver, BC, Canada, Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, BC, Canada
⨯
Stephen Rennard,

Affiliation Division of Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
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Peter D. Paré,

Affiliations The University of British Columbia Centre for Heart Lung Innovation, St Paul’s Hospital, Vancouver, BC, Canada, Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
⨯
Don D. Sin

* E-mail: don.sin@hli.ubc.ca

Affiliations The University of British Columbia Centre for Heart Lung Innovation, St Paul’s Hospital, Vancouver, BC, Canada, Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
⨯

The Effect of Statins on Blood Gene Expression in COPD

Ma’en Obeidat,
Nick Fishbane,
Yunlong Nie,
Virginia Chen,
Zsuzsanna Hollander,
Scott J. Tebbutt,
Yohan Bossé,
Raymond T. Ng,
Bruce E. Miller,
Bruce McManus

Published: October 13, 2015
https://doi.org/10.1371/journal.pone.0140022

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Statins
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Gene expression
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Chronic obstructive pulmonary disease
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Homeostasis
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Blood
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