Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug

Xianzhou Song; Chengwei Zhang; Mingkun Zhao; Hui Chen; Xing Liu; Jianwei Chen; David M. Lonard; Li Qin; Jianming Xu; Xiaosong Wang; Feng Li; Bert W. O’Malley; Jin Wang

doi:10.1371/journal.pone.0140011

Loading metrics

Open Access

Peer-reviewed

Research Article

Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug

Xianzhou Song,

Affiliation Department of Pharmacology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Chengwei Zhang,

Affiliation Department of Pharmacology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Mingkun Zhao,

Affiliations Department of Pharmacology, Baylor College of Medicine, Houston, Texas, United States of America, Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Hui Chen,

Affiliation Department of Pharmacology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Xing Liu,

Affiliation Department of Pharmacology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Jianwei Chen,

Affiliation Department of Pharmacology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
David M. Lonard,

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Li Qin,

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Jianming Xu,

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Xiaosong Wang,

Affiliation Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Feng Li,

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Bert W. O’Malley ,

* E-mail: wangj@bcm.edu (JW); berto@bcm.edu (BWO)

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Jin Wang

* E-mail: wangj@bcm.edu (JW); berto@bcm.edu (BWO)

Affiliations Department of Pharmacology, Baylor College of Medicine, Houston, Texas, United States of America, Center for Drug Discovery, Baylor College of Medicine, Houston, Texas, United States of America
⨯

Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug

Xianzhou Song,
Chengwei Zhang,
Mingkun Zhao,
Hui Chen,
Xing Liu,
Jianwei Chen,
David M. Lonard,
Li Qin,
Jianming Xu,
Xiaosong Wang

Published: October 2, 2015
https://doi.org/10.1371/journal.pone.0140011

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Electrocardiography
Is the Subject Area "Electrocardiography" applicable to this article?

Thanks for your feedback.
Cell motility
Is the Subject Area "Cell motility" applicable to this article?

Thanks for your feedback.
Lung and intrathoracic tumors
Is the Subject Area "Lung and intrathoracic tumors" applicable to this article?

Thanks for your feedback.
Metastasis
Is the Subject Area "Metastasis" applicable to this article?

Thanks for your feedback.
Toxicity
Is the Subject Area "Toxicity" applicable to this article?

Thanks for your feedback.