In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites

Eliška Potůčková; Jaroslav Roh; Miloslav Macháček; Sumit Sahni; Ján Stariat; Vít Šesták; Hana Jansová; Pavlína Hašková; Anna Jirkovská; Kateřina Vávrová; Petra Kovaříková; Danuta S. Kalinowski; Des R. Richardson; Tomáš Šimůnek

doi:10.1371/journal.pone.0139929

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Peer-reviewed

Research Article

In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites

Eliška Potůčková,

Affiliation Department of Biochemical Sciences, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic
⨯
Jaroslav Roh,

Affiliation Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic
⨯
Miloslav Macháček,

Affiliation Department of Biochemical Sciences, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic
⨯
Sumit Sahni,

Affiliation Molecular Pharmacology and Pathology Program, Bosch Institute and Department of Pathology, University of Sydney, Sydney, Australia
⨯
Ján Stariat,

Affiliation Department of Pharmaceutical Chemistry and Drug Analysis, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic
⨯
Vít Šesták,

Affiliation Department of Pharmaceutical Chemistry and Drug Analysis, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic
⨯
Hana Jansová,

Affiliation Department of Biochemical Sciences, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic
⨯
Pavlína Hašková,

Affiliation Department of Biochemical Sciences, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic
⨯
Anna Jirkovská,

Affiliation Department of Biochemical Sciences, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic
⨯
Kateřina Vávrová,

Affiliation Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic
⨯
Petra Kovaříková,

Affiliation Department of Pharmaceutical Chemistry and Drug Analysis, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic
⨯
Danuta S. Kalinowski,

Affiliation Molecular Pharmacology and Pathology Program, Bosch Institute and Department of Pathology, University of Sydney, Sydney, Australia
⨯
Des R. Richardson ,

* E-mail: Tomas.Simunek@faf.cuni.cz (TS); d.richardson@med.usyd.edu.au (DRR)

Affiliation Molecular Pharmacology and Pathology Program, Bosch Institute and Department of Pathology, University of Sydney, Sydney, Australia
⨯
Tomáš Šimůnek

* E-mail: Tomas.Simunek@faf.cuni.cz (TS); d.richardson@med.usyd.edu.au (DRR)

Affiliation Department of Biochemical Sciences, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic
⨯

In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites

Eliška Potůčková,
Jaroslav Roh,
Miloslav Macháček,
Sumit Sahni,
Ján Stariat,
Vít Šesták,
Hana Jansová,
Pavlína Hašková,
Anna Jirkovská,
Kateřina Vávrová

Published: October 13, 2015
https://doi.org/10.1371/journal.pone.0139929

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