Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways

Reynolds K. Brobey; Dwight German; Patricia K. Sonsalla; Prem Gurnani; Johanne Pastor; C-C Hsieh; John Papaconstantinou; Philip P. Foster; Makoto Kuro-o; Kevin P. Rosenblatt

doi:10.1371/journal.pone.0139914

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Peer-reviewed

Research Article

Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways

Reynolds K. Brobey,

Affiliations Centers for Proteomics and Systems Biology, the Brown Foundation Institute of Molecular Medicine, UTHealth Medical School, 1825 Pressler Street, Houston, Texas, United States of America, Division of Oncology, Department of Internal Medicine, UTHealth Medical School, 6410 Fannin, UTPB Suite 722, Houston, Texas, United States of America
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Dwight German,

Affiliation Department of Psychiatry, the University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, United States of America
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Patricia K. Sonsalla,

Affiliation Department of Neurology, UMDNJ Robert Wood Johnson Medical Center, Piscataway, New Jersey, United States of America
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Prem Gurnani,

Affiliation Companion Dx Reference Lab, LLC, 10301 Stella Link Rd., Suite C, Houston, Texas, United States of America
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Johanne Pastor,

Affiliation Department of Psychiatry, the University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, United States of America
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C-C Hsieh,

Affiliation Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America
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John Papaconstantinou,

Affiliation Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America
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Philip P. Foster,

Affiliations Centers for Proteomics and Systems Biology, the Brown Foundation Institute of Molecular Medicine, UTHealth Medical School, 1825 Pressler Street, Houston, Texas, United States of America, Department of NanoMedicine and Biomedical Engineering, MD Anderson Cancer Center Bldg-3SCRB, 1881 East Road, Houston, Texas, United States of America, Division of Pulmonary Medicine, Department of Internal Medicine, 6431 Fannin, MSB 1.274, Houston, Texas, United States of America
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Makoto Kuro-o,

Affiliations Department of Pathology, Center for Mineral Metabolism, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, United States of America, Center for Molecular Medicine, Jichi Medical University, 3311–1 Yakushiji, Shimotsuke, Tochigi, Japan
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Kevin P. Rosenblatt

* E-mail: Kevin.Rosenblatt@uth.tmc.edu

Affiliations Centers for Proteomics and Systems Biology, the Brown Foundation Institute of Molecular Medicine, UTHealth Medical School, 1825 Pressler Street, Houston, Texas, United States of America, Companion Dx Reference Lab, LLC, 10301 Stella Link Rd., Suite C, Houston, Texas, United States of America
⨯

Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways

Reynolds K. Brobey,
Dwight German,
Patricia K. Sonsalla,
Prem Gurnani,
Johanne Pastor,
C-C Hsieh,
John Papaconstantinou,
Philip P. Foster,
Makoto Kuro-o,
Kevin P. Rosenblatt

Published: October 9, 2015
https://doi.org/10.1371/journal.pone.0139914

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