Single and Multiple Dose Pharmacokinetics, Pharmacodynamics and Safety of the Novel Lipoprotein-Associated Phospholipase A2 Enzyme Inhibitor Darapladib in Healthy Chinese Subjects: An Open Label Phase-1 Clinical Trial

Open Access

Peer-reviewed

Research Article

Single and Multiple Dose Pharmacokinetics, Pharmacodynamics and Safety of the Novel Lipoprotein-Associated Phospholipase A₂ Enzyme Inhibitor Darapladib in Healthy Chinese Subjects: An Open Label Phase-1 Clinical Trial

Chaoying Hu,

Affiliation Phase I Clinical Research Unit, Shanghai Xuhui Central Hospital, Shanghai, China
⨯
Debra Tompson ,

* E-mail: yliu@shxh-centerlab.com (YL); debra.j.tompson@gsk.com (DT)

Affiliation Clinical Pharmacology Modeling and Simulation, GSK Medicines Research Centre, Stevenage, United Kingdom
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Mindy Magee,

Affiliation Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
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Qian Chen,

Affiliation Phase I Clinical Research Unit, Shanghai Xuhui Central Hospital, Shanghai, China
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Yan Mei Liu,

Affiliation Phase I Clinical Research Unit, Shanghai Xuhui Central Hospital, Shanghai, China
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Wenjing Zhu,

Affiliation China Medicine Development, GlaxoSmithKline (China) R&D Company Limited, Shanghai, China
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Hongxin Zhao,

Affiliation China Medicine Development, GlaxoSmithKline (China) R&D Company Limited, Shanghai, China
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Annette S. Gross,

Affiliation Ethnopharmacology, GlaxoSmithKline, Sydney, Australia
⨯
Yun Liu

* E-mail: yliu@shxh-centerlab.com (YL); debra.j.tompson@gsk.com (DT)

Affiliation Phase I Clinical Research Unit, Shanghai Xuhui Central Hospital, Shanghai, China
⨯

Chinese people
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Pharmacokinetics
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Adjustment of dosage at steady state
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Blood plasma
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Drug metabolism
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Drug administration
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Pharmacodynamics
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Adverse events
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