A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation

Shiyou Jiang; Jiacheng Du; Qinghua Kong; Chaocui Li; Yan Li; Handong Sun; Jianxin Pu; Bingyu Mao

doi:10.1371/journal.pone.0139830

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Peer-reviewed

Research Article

A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation

Shiyou Jiang,

Affiliations State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China, Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China
⨯
Jiacheng Du,

Affiliations State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China, Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China
⨯
Qinghua Kong,

Affiliation State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
⨯
Chaocui Li,

Affiliation State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
⨯
Yan Li,

Affiliation State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
⨯
Handong Sun,

Affiliation State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
⨯
Jianxin Pu ,

* E-mail: mao@mail.kiz.ac.cn (BM); pujianxin@mail.kib.ac.cn (JP)

Affiliation State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
⨯
Bingyu Mao

* E-mail: mao@mail.kiz.ac.cn (BM); pujianxin@mail.kib.ac.cn (JP)

Affiliation State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
⨯

A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation

Shiyou Jiang,
Jiacheng Du,
Qinghua Kong,
Chaocui Li,
Yan Li,
Handong Sun,
Jianxin Pu,
Bingyu Mao

Published: October 6, 2015
https://doi.org/10.1371/journal.pone.0139830

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Cilia
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Hedgehog signaling
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Signal inhibition
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Terpenes
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