Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells

Riki Okita; Diana Wolf; Koichiro Yasuda; Ai Maeda; Takuro Yukawa; Shinsuke Saisho; Katsuhiko Shimizu; Yoshiyuki Yamaguchi; Mikio Oka; Eiichi Nakayama; Andreas Lundqvist; Rolf Kiessling; Barbara Seliger; Masao Nakata

doi:10.1371/journal.pone.0139809

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Open Access

Peer-reviewed

Research Article

Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells

Riki Okita ,

* E-mail: riki0716okita@yahoo.co.jp

Affiliations Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan, Department of Oncology and Pathology, Immune and Gene Therapy Laboratory, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden
⨯
Diana Wolf,

Affiliation Institute of Medical Immunology, Martin Luther University, Halle-Wittenberg, Halle, Germany
⨯
Koichiro Yasuda,

Affiliation Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan
⨯
Ai Maeda,

Affiliation Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan
⨯
Takuro Yukawa,

Affiliation Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan
⨯
Shinsuke Saisho,

Affiliation Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan
⨯
Katsuhiko Shimizu,

Affiliation Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan
⨯
Yoshiyuki Yamaguchi,

Affiliation Department of Clinical Oncology, Kawasaki Medical School, Kurashiki, Japan
⨯
Mikio Oka,

Affiliation Department of Respiratory Medicine, Kawasaki Medical School, Kurashiki, Japan
⨯
Eiichi Nakayama,

Affiliation Faculty of Health and Welfare, Kawasaki University of Medical Welfare, Kurashiki, Japan
⨯
Andreas Lundqvist,

Affiliation Department of Oncology and Pathology, Immune and Gene Therapy Laboratory, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden
⨯
Rolf Kiessling,

Affiliation Department of Oncology and Pathology, Immune and Gene Therapy Laboratory, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden
⨯
Barbara Seliger,

Affiliation Institute of Medical Immunology, Martin Luther University, Halle-Wittenberg, Halle, Germany
⨯
Masao Nakata

Affiliation Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan
⨯

Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells

Riki Okita,
Diana Wolf,
Koichiro Yasuda,
Ai Maeda,
Takuro Yukawa,
Shinsuke Saisho,
Katsuhiko Shimizu,
Yoshiyuki Yamaguchi,
Mikio Oka,
Eiichi Nakayama

Published: October 6, 2015
https://doi.org/10.1371/journal.pone.0139809

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