Andrographolide Analogue Induces Apoptosis and Autophagy Mediated Cell Death in U937 Cells by Inhibition of PI3K/Akt/mTOR Pathway

Deepak Kumar; Bimolendu Das; Rupashree Sen; Priyanka Kundu; Alak Manna; Avijit Sarkar; Chinmay Chowdhury; Mitali Chatterjee; Padma Das

doi:10.1371/journal.pone.0139657

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Open Access

Peer-reviewed

Research Article

Andrographolide Analogue Induces Apoptosis and Autophagy Mediated Cell Death in U937 Cells by Inhibition of PI3K/Akt/mTOR Pathway

Deepak Kumar,

Affiliation Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata 700 032, India
⨯
Bimolendu Das,

Affiliation Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700 032, India
⨯
Rupashree Sen,

Current address: Department of Otolaryngology, The Johns Hopkins University, School of Medicine, Cancer Research building 1I, Rm 4M61, 1650, Orleans Street, Baltimore, MD, 21287, United States of America

Affiliation Department of Pharmacology, Institute of Post Graduate Medical Education and Research, 244B, A.J.C. Bose Road, Kolkata 700 020, India
⨯
Priyanka Kundu,

Affiliation Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700 032, India
⨯
Alak Manna,

Affiliation Department of Pharmacology, Institute of Post Graduate Medical Education and Research, 244B, A.J.C. Bose Road, Kolkata 700 020, India
⨯
Avijit Sarkar,

Affiliation Department of Pharmacology, Institute of Post Graduate Medical Education and Research, 244B, A.J.C. Bose Road, Kolkata 700 020, India
⨯
Chinmay Chowdhury,

Affiliation Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700 032, India
⨯
Mitali Chatterjee,

Affiliation Department of Pharmacology, Institute of Post Graduate Medical Education and Research, 244B, A.J.C. Bose Road, Kolkata 700 020, India
⨯
Padma Das

* E-mail: padmadas2005@yahoo.co.in

Affiliation Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata 700 032, India
⨯

Andrographolide Analogue Induces Apoptosis and Autophagy Mediated Cell Death in U937 Cells by Inhibition of PI3K/Akt/mTOR Pathway

Deepak Kumar,
Bimolendu Das,
Rupashree Sen,
Priyanka Kundu,
Alak Manna,
Avijit Sarkar,
Chinmay Chowdhury,
Mitali Chatterjee,
Padma Das

Published: October 5, 2015
https://doi.org/10.1371/journal.pone.0139657

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Apoptosis
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Cancer treatment
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Cell staining
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