Bayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant Populations

Open Access

Peer-reviewed

Research Article

Markus Krauss,

Affiliations Computational Systems Biology, Bayer Technology Services GmbH, Leverkusen, Germany, Aachen Institute for Advanced Study in Computational Engineering Sciences, RWTH Aachen, Aachen, Germany
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Kai Tappe,

Affiliation Computational Systems Biology, Bayer Technology Services GmbH, Leverkusen, Germany
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Andreas Schuppert,

Affiliations Computational Systems Biology, Bayer Technology Services GmbH, Leverkusen, Germany, Aachen Institute for Advanced Study in Computational Engineering Sciences, RWTH Aachen, Aachen, Germany
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Lars Kuepfer,

Affiliation Computational Systems Biology, Bayer Technology Services GmbH, Leverkusen, Germany
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Linus Goerlitz

* E-mail: Linus.Goerlitz@Bayer.com

Affiliation Computational Systems Biology, Bayer Technology Services GmbH, Leverkusen, Germany
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Markov models
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