Oseltamivir Resistance in Influenza A(H6N2) Caused by an R292K Substitution in Neuraminidase Is Not Maintained in Mallards without Drug Pressure

Anna Gillman; Shaman Muradrasoli; Andreas Mårdnäs; Hanna Söderström; Ganna Fedorova; Max Löwenthal; Michelle Wille; Annika Daggfeldt; Josef D. Järhult

doi:10.1371/journal.pone.0139415

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Open Access

Peer-reviewed

Research Article

Oseltamivir Resistance in Influenza A(H6N2) Caused by an R292K Substitution in Neuraminidase Is Not Maintained in Mallards without Drug Pressure

Anna Gillman ,

* E-mail: anna.gillman@medsci.uu.se

Affiliations Section for Infectious Diseases, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Zoonosis Science Centre, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
⨯
Shaman Muradrasoli,

Affiliation Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden
⨯
Andreas Mårdnäs,

Affiliations Section for Infectious Diseases, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Zoonosis Science Centre, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
⨯
Hanna Söderström,

Affiliation Department of Chemistry, Umeå University, Umeå, Sweden
⨯
Ganna Fedorova,

Affiliations Department of Chemistry, Umeå University, Umeå, Sweden, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodnany, University of South Bohemia in Ceske Budejovice, Ceske Budejovice, Czech Republic
⨯
Max Löwenthal,

Affiliations Section for Infectious Diseases, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Zoonosis Science Centre, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
⨯
Michelle Wille,

Affiliation Centre for Ecology and Evolution in Microbial Model Systems, Linnaeus University, Kalmar, Sweden
⨯
Annika Daggfeldt,

Affiliation Department of Virology, Immunobiology and Parasitology, Swedish Veterinary Institute, Uppsala, Sweden
⨯
Josef D. Järhult

Affiliations Section for Infectious Diseases, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Zoonosis Science Centre, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
⨯

Oseltamivir Resistance in Influenza A(H6N2) Caused by an R292K Substitution in Neuraminidase Is Not Maintained in Mallards without Drug Pressure

Anna Gillman,
Shaman Muradrasoli,
Andreas Mårdnäs,
Hanna Söderström,
Ganna Fedorova,
Max Löwenthal,
Michelle Wille,
Annika Daggfeldt,
Josef D. Järhult

Published: September 30, 2015
https://doi.org/10.1371/journal.pone.0139415

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