MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation

Gautam Borthakur; Seshagiri Duvvuri; Vivian Ruvolo; Durga Nand Tripathi; Sujan Piya; Jared Burks; Rodrigo Jacamo; Kensuke Kojima; Peter Ruvolo; Juan Fueyo-Margareto; Marina Konopleva; Michael Andreeff

doi:10.1371/journal.pone.0139254

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Peer-reviewed

Research Article

MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation

Gautam Borthakur,

Affiliation Section of Molecular Hematology and Therapy; Departments of Leukemia and Stem Cell Transplantation, UT MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Seshagiri Duvvuri,

Affiliation Section of Molecular Hematology and Therapy; Departments of Leukemia and Stem Cell Transplantation, UT MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Vivian Ruvolo,

Affiliation Section of Molecular Hematology and Therapy; Departments of Leukemia and Stem Cell Transplantation, UT MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Durga Nand Tripathi,

Affiliation Centre for Translational Cancer Research, Institute for Biosciences & Technology, Texas A&M Health Science Center, Houston, Texas, United States of America
⨯
Sujan Piya,

Affiliation Section of Molecular Hematology and Therapy; Departments of Leukemia and Stem Cell Transplantation, UT MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Jared Burks,

Affiliation Section of Molecular Hematology and Therapy; Departments of Leukemia and Stem Cell Transplantation, UT MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Rodrigo Jacamo,

Affiliation Section of Molecular Hematology and Therapy; Departments of Leukemia and Stem Cell Transplantation, UT MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Kensuke Kojima,

Affiliation Section of Molecular Hematology and Therapy; Departments of Leukemia and Stem Cell Transplantation, UT MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Peter Ruvolo,

Affiliation Section of Molecular Hematology and Therapy; Departments of Leukemia and Stem Cell Transplantation, UT MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Juan Fueyo-Margareto,

Affiliation Department of Neuro-oncology, UT MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Marina Konopleva,

Affiliation Section of Molecular Hematology and Therapy; Departments of Leukemia and Stem Cell Transplantation, UT MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Michael Andreeff

* E-mail: mandreef@mdanderson.org

Affiliation Section of Molecular Hematology and Therapy; Departments of Leukemia and Stem Cell Transplantation, UT MD Anderson Cancer Center, Houston, Texas, United States of America
⨯

MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation

Gautam Borthakur,
Seshagiri Duvvuri,
Vivian Ruvolo,
Durga Nand Tripathi,
Sujan Piya,
Jared Burks,
Rodrigo Jacamo,
Kensuke Kojima,
Peter Ruvolo,
Juan Fueyo-Margareto

Published: October 6, 2015
https://doi.org/10.1371/journal.pone.0139254

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