Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor

Sandra Gouveia-Figueira; Jessica Karlsson; Alessandro Deplano; Sanaz Hashemian; Mona Svensson; Marcus Fredriksson Sundbom; Cenzo Congiu; Valentina Onnis; Christopher J. Fowler

doi:10.1371/journal.pone.0139212

Loading metrics

Open Access

Peer-reviewed

Research Article

Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor

Sandra Gouveia-Figueira,

Affiliations Department of Pharmacology and Clinical Neuroscience, Pharmacology Unit, Umeå University, Umeå, Sweden, Department of Chemistry, Umeå University, Umeå, Sweden
⨯
Jessica Karlsson,

Affiliation Department of Pharmacology and Clinical Neuroscience, Pharmacology Unit, Umeå University, Umeå, Sweden
⨯
Alessandro Deplano,

Affiliation Department of Life and Environmental Sciences, Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences, University of Cagliari, via Ospedale 72, Cagliari, Italy
⨯
Sanaz Hashemian,

Affiliation Department of Pharmacology and Clinical Neuroscience, Pharmacology Unit, Umeå University, Umeå, Sweden
⨯
Mona Svensson,

Affiliation Department of Pharmacology and Clinical Neuroscience, Pharmacology Unit, Umeå University, Umeå, Sweden
⨯
Marcus Fredriksson Sundbom,

Affiliation Department of Pharmacology and Clinical Neuroscience, Pharmacology Unit, Umeå University, Umeå, Sweden
⨯
Cenzo Congiu,

Affiliation Department of Life and Environmental Sciences, Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences, University of Cagliari, via Ospedale 72, Cagliari, Italy
⨯
Valentina Onnis,

Affiliation Department of Life and Environmental Sciences, Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences, University of Cagliari, via Ospedale 72, Cagliari, Italy
⨯
Christopher J. Fowler

* E-mail: cf@pharm.umu.se

Affiliation Department of Pharmacology and Clinical Neuroscience, Pharmacology Unit, Umeå University, Umeå, Sweden
⨯

Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor

Sandra Gouveia-Figueira,
Jessica Karlsson,
Alessandro Deplano,
Sanaz Hashemian,
Mona Svensson,
Marcus Fredriksson Sundbom,
Cenzo Congiu,
Valentina Onnis,
Christopher J. Fowler

Published: September 25, 2015
https://doi.org/10.1371/journal.pone.0139212

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

COX-2 inhibitors
Is the Subject Area "COX-2 inhibitors" applicable to this article?

Thanks for your feedback.
Enantiomers
Is the Subject Area "Enantiomers" applicable to this article?

Thanks for your feedback.
Lipids
Is the Subject Area "Lipids" applicable to this article?

Thanks for your feedback.
Prostaglandin
Is the Subject Area "Prostaglandin" applicable to this article?

Thanks for your feedback.
Hydrolysis
Is the Subject Area "Hydrolysis" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
NSAIDs
Is the Subject Area "NSAIDs" applicable to this article?

Thanks for your feedback.
Amides
Is the Subject Area "Amides" applicable to this article?

Thanks for your feedback.