Insight into the Mechanism of Intramolecular Inhibition of the Catalytic Activity of Sirtuin 2 (SIRT2)

• Jinyu Li,

  Affiliations Computational Biomedicine, Institute for Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Forschungszentrum Jülich, 52425, Jülich, Germany, Institute of Biochemistry and Molecular Biology, RWTH Aachen University, 52057, Aachen, Germany

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• Franziska Flick,

  Affiliation Institute of Biochemistry and Molecular Biology, RWTH Aachen University, 52057, Aachen, Germany

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• Patricia Verheugd,

  Affiliation Institute of Biochemistry and Molecular Biology, RWTH Aachen University, 52057, Aachen, Germany

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• Paolo Carloni,

  Affiliations Computational Biomedicine, Institute for Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Forschungszentrum Jülich, 52425, Jülich, Germany, Computational Biophysics, German Research School for Simulation Sciences, Forschungszentrum Jülich, 52425, Jülich, Germany

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• Bernhard Lüscher ,

  ¶‡ These authors are joint senior authors on this work.

  Affiliation Institute of Biochemistry and Molecular Biology, RWTH Aachen University, 52057, Aachen, Germany

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• Giulia Rossetti

  * E-mail: g.rossetti@fz-juelich.de

  ¶‡ These authors are joint senior authors on this work.

  Affiliations Computational Biomedicine, Institute for Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Forschungszentrum Jülich, 52425, Jülich, Germany, Jülich Supercomputing Centre, Forschungszentrum Jülich, 52425, Jülich, Germany, Department of Oncology, Hematology and Stem Cell Transplantation, RWTH Aachen University, Aachen, Germany

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