Establishment of Homozygote Mutant Human Embryonic Stem Cells by Parthenogenesis

Silvina Epsztejn-Litman; Yaara Cohen-Hadad; Shira Aharoni; Gheona Altarescu; Paul Renbaum; Ephrat Levy-Lahad; Oshrat Schonberger; Talia Eldar-Geva; Sharon Zeligson; Rachel Eiges

doi:10.1371/journal.pone.0138893

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Peer-reviewed

Research Article

Establishment of Homozygote Mutant Human Embryonic Stem Cells by Parthenogenesis

Silvina Epsztejn-Litman,

Affiliation Stem Cell Research Laboratory, Shaare Zedek Medical Center affiliated with the Hebrew University School of Medicine, Jerusalem, Israel
⨯
Yaara Cohen-Hadad,

Affiliation Stem Cell Research Laboratory, Shaare Zedek Medical Center affiliated with the Hebrew University School of Medicine, Jerusalem, Israel
⨯
Shira Aharoni,

Affiliation Stem Cell Research Laboratory, Shaare Zedek Medical Center affiliated with the Hebrew University School of Medicine, Jerusalem, Israel
⨯
Gheona Altarescu,

Affiliation Zohar PGD Lab, Medical Genetics Institute, Shaare Zedek Medical Center affiliated with the Hebrew University School of Medicine, Jerusalem, Israel
⨯
Paul Renbaum,

Affiliation Zohar PGD Lab, Medical Genetics Institute, Shaare Zedek Medical Center affiliated with the Hebrew University School of Medicine, Jerusalem, Israel
⨯
Ephrat Levy-Lahad,

Affiliation Zohar PGD Lab, Medical Genetics Institute, Shaare Zedek Medical Center affiliated with the Hebrew University School of Medicine, Jerusalem, Israel
⨯
Oshrat Schonberger,

Affiliation IVF Unit, Shaare Zedek Medical Center affiliated with the Hebrew University School of Medicine, Jerusalem, Israel
⨯
Talia Eldar-Geva,

Affiliation IVF Unit, Shaare Zedek Medical Center affiliated with the Hebrew University School of Medicine, Jerusalem, Israel
⨯
Sharon Zeligson,

Affiliation Zohar PGD Lab, Medical Genetics Institute, Shaare Zedek Medical Center affiliated with the Hebrew University School of Medicine, Jerusalem, Israel
⨯
Rachel Eiges

* E-mail: rachela@szmc.org.il

Affiliation Stem Cell Research Laboratory, Shaare Zedek Medical Center affiliated with the Hebrew University School of Medicine, Jerusalem, Israel
⨯

Establishment of Homozygote Mutant Human Embryonic Stem Cells by Parthenogenesis

Silvina Epsztejn-Litman,
Yaara Cohen-Hadad,
Shira Aharoni,
Gheona Altarescu,
Paul Renbaum,
Ephrat Levy-Lahad,
Oshrat Schonberger,
Talia Eldar-Geva,
Sharon Zeligson,
Rachel Eiges

Published: October 16, 2015
https://doi.org/10.1371/journal.pone.0138893

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Homozygosity
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DNA methylation
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Single nucleotide polymorphisms
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Parthenogenesis
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Oocytes
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Heterozygosity
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Genomic imprinting
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Genetic loci
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