In Vivo Evolution of Bacterial Resistance in Two Cases of Enterobacter aerogenes Infections during Treatment with Imipenem

Nadège Philippe; Laure Maigre; Sébastien Santini; Elizabeth Pinet; Jean-Michel Claverie; Anne-Véronique Davin-Régli; Jean-Marie Pagès; Muriel Masi

doi:10.1371/journal.pone.0138828

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Peer-reviewed

Research Article

In Vivo Evolution of Bacterial Resistance in Two Cases of Enterobacter aerogenes Infections during Treatment with Imipenem

Nadège Philippe ,

Contributed equally to this work with: Nadège Philippe, Laure Maigre

Current address: Laboratoire Information Génomique et Structurale–CNRS UMR7256 –Institut de Microbiologie de la Méditerranée (IMM, FR3479) Parc Scientifique de Luminy– 163 Avenue de Luminy–Case 934 FR-13288, Marseille cedex 09, France,

Affiliation UMR-MD1 –Transporteurs Membranaires, Chimiorésistance et Drug Design–Aix-Marseille Université et Institut de Recherche Biomédicale des Armées (IRBA), 27 Boulevard Jean Moulin, 13385 Marseille cedex 05, France
⨯
Laure Maigre ,

Contributed equally to this work with: Nadège Philippe, Laure Maigre

Affiliation UMR-MD1 –Transporteurs Membranaires, Chimiorésistance et Drug Design–Aix-Marseille Université et Institut de Recherche Biomédicale des Armées (IRBA), 27 Boulevard Jean Moulin, 13385 Marseille cedex 05, France
⨯
Sébastien Santini,

Affiliation Laboratoire Information Génomique et Structurale–CNRS UMR7256 –Institut de Microbiologie de la Méditerranée (IMM, FR3479) Parc Scientifique de Luminy– 163 Avenue de Luminy–Case 934 FR-13288, Marseille cedex 09, France
⨯
Elizabeth Pinet,

Current address: Mérieux NutriSciences Laboratoire de Microbiologie—12 rue Flemming Parc Technologique, 17071 La Rochelle cedex 9, France

Affiliation UMR-MD1 –Transporteurs Membranaires, Chimiorésistance et Drug Design–Aix-Marseille Université et Institut de Recherche Biomédicale des Armées (IRBA), 27 Boulevard Jean Moulin, 13385 Marseille cedex 05, France
⨯
Jean-Michel Claverie,

Affiliation Laboratoire Information Génomique et Structurale–CNRS UMR7256 –Institut de Microbiologie de la Méditerranée (IMM, FR3479) Parc Scientifique de Luminy– 163 Avenue de Luminy–Case 934 FR-13288, Marseille cedex 09, France
⨯
Anne-Véronique Davin-Régli,

Affiliation UMR-MD1 –Transporteurs Membranaires, Chimiorésistance et Drug Design–Aix-Marseille Université et Institut de Recherche Biomédicale des Armées (IRBA), 27 Boulevard Jean Moulin, 13385 Marseille cedex 05, France
⨯
Jean-Marie Pagès,

Affiliation UMR-MD1 –Transporteurs Membranaires, Chimiorésistance et Drug Design–Aix-Marseille Université et Institut de Recherche Biomédicale des Armées (IRBA), 27 Boulevard Jean Moulin, 13385 Marseille cedex 05, France
⨯
Muriel Masi

* E-mail: muriel.masi@univ-amu.fr

Affiliation UMR-MD1 –Transporteurs Membranaires, Chimiorésistance et Drug Design–Aix-Marseille Université et Institut de Recherche Biomédicale des Armées (IRBA), 27 Boulevard Jean Moulin, 13385 Marseille cedex 05, France
⨯

In Vivo Evolution of Bacterial Resistance in Two Cases of Enterobacter aerogenes Infections during Treatment with Imipenem

Nadège Philippe,
Laure Maigre,
Sébastien Santini,
Elizabeth Pinet,
Jean-Michel Claverie,
Anne-Véronique Davin-Régli,
Jean-Marie Pagès,
Muriel Masi

Published: September 23, 2015
https://doi.org/10.1371/journal.pone.0138828

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