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Open Access
Peer-reviewed
Research Article
Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection
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Chu-Hsun Cheng,
Affiliations Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan, Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
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Chi-Te Lin,
Affiliations Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Nursing, Central Taiwan University of Science and Technology, Taichung, Taiwan
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Meng-Jen Lee,
Affiliations Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Applied Chemistry, Chaoyang University of Technology, Taichung, Taiwan
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May-Jywan Tsai,
Affiliation Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
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Wen-Hung Huang,
Affiliation Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
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Ming-Chao Huang,
Affiliations Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, Division of Pediatric Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, School of Medicine, Taipei Medical University, Taipei, Taiwan
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Yi-Lo Lin,
Affiliations Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, Graduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
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Ching-Jung Chen,
Affiliation Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
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Wen-Cheng Huang ,
Contributed equally to this work with: Wen-Cheng Huang, Henrich Cheng
* E-mail: wchuang518@gmail.com
Affiliations Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, Center for Neural Regeneration, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Medicine, National Yang-Ming University, Taipei, Taiwan
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Henrich Cheng
Contributed equally to this work with: Wen-Cheng Huang, Henrich Cheng
Affiliations Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan, Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, Center for Neural Regeneration, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Medicine, National Yang-Ming University, Taipei, Taiwan
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Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection
- Chu-Hsun Cheng,
- Chi-Te Lin,
- Meng-Jen Lee,
- May-Jywan Tsai,
- Wen-Hung Huang,
- Ming-Chao Huang,
- Yi-Lo Lin,
- Ching-Jung Chen,
- Wen-Cheng Huang,
- Henrich Cheng
- Published: September 22, 2015
- https://doi.org/10.1371/journal.pone.0138705