mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis

Yao-Song Gui; Lianmei Wang; Xinlun Tian; Xue Li; Aiping Ma; Weixun Zhou; Ni Zeng; Ji Zhang; Baiqiang Cai; Hongbing Zhang; Jing-Yu Chen; Kai-Feng Xu

doi:10.1371/journal.pone.0138625

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Open Access

Peer-reviewed

Research Article

mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis

Yao-Song Gui,

Affiliation Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
⨯
Lianmei Wang,

Affiliations State Key Laboratory of Medical Molecular Biology, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
⨯
Xinlun Tian,

Affiliation Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
⨯
Xue Li,

Affiliation Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
⨯
Aiping Ma,

Affiliation Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
⨯
Weixun Zhou,

Affiliation Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
⨯
Ni Zeng,

Affiliation Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
⨯
Ji Zhang,

Affiliation Department of Thoracic Surgery, Wuxi People’s Hospital affiliated to Nanjing Medical University, Wuxi, China
⨯
Baiqiang Cai,

Affiliation Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
⨯
Hongbing Zhang,

Affiliation State Key Laboratory of Medical Molecular Biology, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
⨯
Jing-Yu Chen ,

* E-mail: chenjingyu333@sina.com (JYC); kaifeng.xu@gmail.com (KFX)

Affiliation Department of Thoracic Surgery, Wuxi People’s Hospital affiliated to Nanjing Medical University, Wuxi, China
⨯
Kai-Feng Xu

* E-mail: chenjingyu333@sina.com (JYC); kaifeng.xu@gmail.com (KFX)

Affiliation Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
⨯

mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis

Yao-Song Gui,
Lianmei Wang,
Xinlun Tian,
Xue Li,
Aiping Ma,
Weixun Zhou,
Ni Zeng,
Ji Zhang,
Baiqiang Cai,
Hongbing Zhang

Published: September 18, 2015
https://doi.org/10.1371/journal.pone.0138625

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