Natural Killer Cells Improve Hematopoietic Stem Cell Engraftment by Increasing Stem Cell Clonogenicity In Vitro and in a Humanized Mouse Model

Michelle Escobedo-Cousin; Nicola Jackson; Raquel Laza-Briviesca; Linda Ariza-McNaughton; Martha Luevano; Sophie Derniame; Sergio Querol; Michael Blundell; Adrian Thrasher; Bernat Soria; Nichola Cooper; Dominique Bonnet; Alejandro Madrigal; Aurore Saudemont

doi:10.1371/journal.pone.0138623

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Peer-reviewed

Research Article

Natural Killer Cells Improve Hematopoietic Stem Cell Engraftment by Increasing Stem Cell Clonogenicity In Vitro and in a Humanized Mouse Model

Michelle Escobedo-Cousin ,

Contributed equally to this work with: Michelle Escobedo-Cousin, Nicola Jackson

Affiliations University College London, Cancer Institute, London, United Kingdom, Anthony Nolan Research Institute, Royal Free Campus, London, United Kingdom
⨯
Nicola Jackson ,

Contributed equally to this work with: Michelle Escobedo-Cousin, Nicola Jackson

Affiliation Anthony Nolan Research Institute, Royal Free Campus, London, United Kingdom
⨯
Raquel Laza-Briviesca,

Affiliation Anthony Nolan Research Institute, Royal Free Campus, London, United Kingdom
⨯
Linda Ariza-McNaughton,

Affiliation Cancer Research UK, London Research Institute, London, United Kingdom
⨯
Martha Luevano,

Affiliations University College London, Cancer Institute, London, United Kingdom, Anthony Nolan Research Institute, Royal Free Campus, London, United Kingdom
⨯
Sophie Derniame,

Affiliations University College London, Cancer Institute, London, United Kingdom, Anthony Nolan Research Institute, Royal Free Campus, London, United Kingdom
⨯
Sergio Querol,

Affiliation Programa Concordia Banc de Sang i Teixits, Barcelona, Spain
⨯
Michael Blundell,

Affiliation University College London, Institute of Child Health, London, United Kingdom
⨯
Adrian Thrasher,

Affiliation University College London, Institute of Child Health, London, United Kingdom
⨯
Bernat Soria,

Affiliations Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), Fundación Progreso y Salud, Seville, Spain, Biomedical Research Network on Diabetes and Related Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain
⨯
Nichola Cooper,

Affiliation Haematology Department, Hammersmith Hospital, London, United Kingdom
⨯
Dominique Bonnet,

Affiliation Cancer Research UK, London Research Institute, London, United Kingdom
⨯
Alejandro Madrigal,

Affiliations University College London, Cancer Institute, London, United Kingdom, Anthony Nolan Research Institute, Royal Free Campus, London, United Kingdom
⨯
Aurore Saudemont

* E-mail: aurore.saudemont@anthonynolan.org

Affiliations University College London, Cancer Institute, London, United Kingdom, Anthony Nolan Research Institute, Royal Free Campus, London, United Kingdom
⨯

Natural Killer Cells Improve Hematopoietic Stem Cell Engraftment by Increasing Stem Cell Clonogenicity In Vitro and in a Humanized Mouse Model

Michelle Escobedo-Cousin,
Nicola Jackson,
Raquel Laza-Briviesca,
Linda Ariza-McNaughton,
Martha Luevano,
Sophie Derniame,
Sergio Querol,
Michael Blundell,
Adrian Thrasher,
Bernat Soria

Published: October 14, 2015
https://doi.org/10.1371/journal.pone.0138623

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