Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity

Cristina Cheroni; Lorena Donnici; Alessio Aghemo; Francesca Balistreri; Annalisa Bianco; Valeria Zanoni; Massimiliano Pagani; Roberta Soffredini; Roberta D’Ambrosio; Maria Grazia Rumi; Massimo Colombo; Sergio Abrignani; Petra Neddermann; Raffaele De Francesco

doi:10.1371/journal.pone.0138546

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Peer-reviewed

Research Article

Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity

Cristina Cheroni ,

Contributed equally to this work with: Cristina Cheroni, Lorena Donnici

Affiliation INGM, Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”, Milan, Italy
⨯
Lorena Donnici ,

Contributed equally to this work with: Cristina Cheroni, Lorena Donnici

Affiliation INGM, Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”, Milan, Italy
⨯
Alessio Aghemo,

Affiliation A.M. Migliavacca Center for Liver Disease, First Division of Gastroenterology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico Milano, Università degli Studi di Milano, Milan, Italy
⨯
Francesca Balistreri,

Affiliation INGM, Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”, Milan, Italy
⨯
Annalisa Bianco,

Affiliation INGM, Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”, Milan, Italy
⨯
Valeria Zanoni,

Affiliation INGM, Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”, Milan, Italy
⨯
Massimiliano Pagani,

Affiliation INGM, Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”, Milan, Italy
⨯
Roberta Soffredini,

Affiliation A.M. Migliavacca Center for Liver Disease, First Division of Gastroenterology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico Milano, Università degli Studi di Milano, Milan, Italy
⨯
Roberta D’Ambrosio,

Affiliation A.M. Migliavacca Center for Liver Disease, First Division of Gastroenterology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico Milano, Università degli Studi di Milano, Milan, Italy
⨯
Maria Grazia Rumi,

Affiliation Division of Hepatology, Ospedale San Giuseppe IRCCS Multimedica, Università degli Studi di Milano, Milan, Italy
⨯
Massimo Colombo,

Affiliation A.M. Migliavacca Center for Liver Disease, First Division of Gastroenterology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico Milano, Università degli Studi di Milano, Milan, Italy
⨯
Sergio Abrignani,

Affiliations INGM, Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”, Milan, Italy, DISCCO, Department of Clinical Sciences and Community Health Università degli Studi di Milano, Milan, Italy
⨯
Petra Neddermann,

Affiliation INGM, Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”, Milan, Italy
⨯
Raffaele De Francesco

* E-mail: defrancesco@ingm.org

Affiliation INGM, Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”, Milan, Italy
⨯

Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity

Cristina Cheroni,
Lorena Donnici,
Alessio Aghemo,
Francesca Balistreri,
Annalisa Bianco,
Valeria Zanoni,
Massimiliano Pagani,
Roberta Soffredini,
Roberta D’Ambrosio,
Maria Grazia Rumi

Published: September 25, 2015
https://doi.org/10.1371/journal.pone.0138546

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