Characterizing Heterogeneity within Head and Neck Lesions Using Cluster Analysis of Multi-Parametric MRI Data

Marco Borri; Maria A. Schmidt; Ceri Powell; Dow-Mu Koh; Angela M. Riddell; Mike Partridge; Shreerang A. Bhide; Christopher M. Nutting; Kevin J. Harrington; Katie L. Newbold; Martin O. Leach

doi:10.1371/journal.pone.0138545

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Open Access

Peer-reviewed

Research Article

Characterizing Heterogeneity within Head and Neck Lesions Using Cluster Analysis of Multi-Parametric MRI Data

Marco Borri ,

* E-mail: marco.borri@icr.ac.uk

Affiliation CR-UK Cancer Imaging Centre, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, London, United Kingdom
⨯
Maria A. Schmidt,

Affiliation CR-UK Cancer Imaging Centre, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, London, United Kingdom
⨯
Ceri Powell,

Affiliation Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯
Dow-Mu Koh,

Affiliations CR-UK Cancer Imaging Centre, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, London, United Kingdom, Radiology Department, The Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯
Angela M. Riddell,

Affiliation Radiology Department, The Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯
Mike Partridge,

Affiliation CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom
⨯
Shreerang A. Bhide,

Affiliation Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯
Christopher M. Nutting,

Affiliation Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯
Kevin J. Harrington,

Affiliation Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯
Katie L. Newbold,

Affiliation Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯
Martin O. Leach

Affiliation CR-UK Cancer Imaging Centre, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, London, United Kingdom
⨯

Characterizing Heterogeneity within Head and Neck Lesions Using Cluster Analysis of Multi-Parametric MRI Data

Marco Borri,
Maria A. Schmidt,
Ceri Powell,
Dow-Mu Koh,
Angela M. Riddell,
Mike Partridge,
Shreerang A. Bhide,
Christopher M. Nutting,
Kevin J. Harrington,
Katie L. Newbold

Published: September 23, 2015
https://doi.org/10.1371/journal.pone.0138545

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Clustering algorithms
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Cancer treatment
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Diffusion weighted imaging
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Adenocarcinoma
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Head and neck cancers
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Magnetic resonance imaging
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Principal component analysis
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