Biodiversity, Anti-Trypanosomal Activity Screening, and Metabolomic Profiling of Actinomycetes Isolated from Mediterranean Sponges

Cheng Cheng; Lynsey MacIntyre; Usama Ramadan Abdelmohsen; Hannes Horn; Paraskevi N. Polymenakou; RuAngelie Edrada-Ebel; Ute Hentschel

doi:10.1371/journal.pone.0138528

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Research Article

Biodiversity, Anti-Trypanosomal Activity Screening, and Metabolomic Profiling of Actinomycetes Isolated from Mediterranean Sponges

Cheng Cheng,

Affiliation Dept. of Botany II, Julius-von-Sachs Institute for Biological Sciences, University of Würzburg, Würzburg, Germany
⨯
Lynsey MacIntyre,

Affiliation Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom
⨯
Usama Ramadan Abdelmohsen,

Affiliation Dept. of Botany II, Julius-von-Sachs Institute for Biological Sciences, University of Würzburg, Würzburg, Germany
⨯
Hannes Horn,

Current Address: GEOMAR Helmholtz Centre for Ocean Research, RD3 Marine Microbiology and Christian-Albrechts-University of Kiel, Kiel, Germany

Affiliation Dept. of Botany II, Julius-von-Sachs Institute for Biological Sciences, University of Würzburg, Würzburg, Germany
⨯
Paraskevi N. Polymenakou,

Affiliation Hellenic Centre for Marine Research, Institute of Marine Biology, Biotechnology and Aquaculture, Gournes Pediados, Heraklion, Crete, Greece
⨯
RuAngelie Edrada-Ebel ,

* E-mail: ruangelie.edrada-ebel@strath.ac.uk (RE-E); ute.hentschel@uni-wuerzburg.de (UH)

Affiliation Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom
⨯
Ute Hentschel

* E-mail: ruangelie.edrada-ebel@strath.ac.uk (RE-E); ute.hentschel@uni-wuerzburg.de (UH)

Current Address: GEOMAR Helmholtz Centre for Ocean Research, RD3 Marine Microbiology and Christian-Albrechts-University of Kiel, Kiel, Germany

Affiliation Dept. of Botany II, Julius-von-Sachs Institute for Biological Sciences, University of Würzburg, Würzburg, Germany
⨯

Biodiversity, Anti-Trypanosomal Activity Screening, and Metabolomic Profiling of Actinomycetes Isolated from Mediterranean Sponges

Cheng Cheng,
Lynsey MacIntyre,
Usama Ramadan Abdelmohsen,
Hannes Horn,
Paraskevi N. Polymenakou,
RuAngelie Edrada-Ebel,
Ute Hentschel

Published: September 25, 2015
https://doi.org/10.1371/journal.pone.0138528

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Sponges
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Actinobacteria
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Streptomyces
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Metabolites
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Principal component analysis
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Secondary metabolites
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Metabolomics
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Ribosomal RNA
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